STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0978L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa)    
Predicted Functional Partners:
SCO3383
Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
 
 0.999
SCO2256
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate.; Belongs to the PanB family.
 
  
 0.984
SCO3622
SC66T3.33, probable aminotransferase, len: 451 aa; similar to many e.g. SW:GABT_ECOLI (EMBL:M88334), gabT, Escherichia coli 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 706 z-score: 815.4 E(): 0, 32.3% identity in 427 aa overlap. Also similar to TR:O86744 (EMBL:AL031035) S.coelicolor probable aminotransferase (457 aa) (37.3% identity in 362 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate [...]
    
 0.919
SCO1706
SCI30A.27c, probable aldehyde dehydrogenase, len: 462 aa; similar to many e.g. TR:O33455 (EMBL:U24215) P-cumic aldehyde dehydrogenase from Pseudomonas putida Fl (494 aa) fasta scores; opt: 1109, z-score: 1142.8, E(): 0, (44.6% identity in 471 aa overlap) and TR:O88069 (EMBL:AL031541) putative aldehyde dehydrogenase from Streptomyces coelicolor (483 aa) fasta scores; opt: 1011, z-score: 1042.5, E(): 0, (41.8% identity in 466 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site.
     
 0.909
SCO3420
SCE9.27c, probable aldehyde dehydrogenase, len: 486 aa; highly similar to many NAD-linked aldehyde dehydrogenases e.g. SW:XYLC_PSEPU (EMBL:U15151), xylC, Pseudomonas putida benzaldehyde dehydrogenase [NAD+] from TOL plasmid pWW0 (487 aa), fasta scores; opt: 1244 z-score: 1420.3 E(): 0, 41.5% identity in 479 aa overlap. Similar to others from S.coelicolor e.g. TR:O88069 (EMBL:AL031541) probable aldehyde dehydrogenase (483 aa) (40.0% identity in 448 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 491.30, E-value 7.6e-144, PS00687 Aldehyde dehydroge [...]
     
 0.909
SCO4913
SCK13.05c, probable aldehyde dehydrogenase, len: aa; similar to SW:DHA5_YEAST (EMBL:X85987) Saccharomyces cerevisiae aldehyde dehydrogenase 2 (EC 1.2.1.5) Ald5, 506 aa; fasta scores: opt: 1336 z-score: 1519.8 E(): 0; 46.1% identity in 462 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00070 Aldehyde dehydrogenases cysteine active site.
     
 0.909
SCO5676
SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.909
SCO5679
SC5H4.03, probable aldehyde dehydrogenase, len: 481 aa; similar to TR:O66573 (EMBL:AE000677) Aquifex aeolicus aldehyde dehydrogenase AldH1, 476 aa; fasta scores: opt: 1129 z-score: 1260.2 E(): 0; 39.9% identity in 471 aa overlap and to SW:GAPN_STRMU (EMBL:L38521) Streptococcus mutans NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) GapN, 475 aa; fasta scores: opt: 893 z-score: 997.5 E(): 0; 35.4% identity in 477 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family.
     
 0.909
SCO6412
SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...]
     
 0.909
SCO7034
SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...]
     
 0.909
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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