STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1041Conserved hypothetical protein SCG20A.21; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (407 aa)    
Predicted Functional Partners:
SCO1039
SCG20A.19c, possible ROK family regulatory protein, len: 412 aa; similar to TR:O50502 (EMBL:AL009199) Streptomyces coelicolor probable transcriptional repressor protein SC7B7.05, 403 aa; fasta scores: opt: 456 z-score: 485.8 E(): 1.4e-19; 27.7% identity in 390 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family.
       0.759
SCO2595
GTP-binding protein; Plays an unknown essential role and a regulatory role in sporulation. Overexpression suppresses sporulation although cell growth rate was not reduced. Impaired differentiation was eliminated by addition of decoyinine, an inhibitor of GMP synthesis. Overexpression has no effect on undecylprodigiosin production, but decreases actinorhodin production.
   
  
 0.746
SCO1040
SCG20A.20c, probable DNA repair protein, len: 216 aa; similar to SW:ALKB_ECOLI (EMBL:J02607) Escherichia coli DNA repair protein AlkB, 216 aa; fasta scores: opt: 302 z-score: 361.8 E(): 1.1e-12; 34.3% identity in 207 aa overlap.
       0.648
SCO4649
50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
  
    0.634
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
    0.604
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.597
SCO4647
Transcription antitermination protein; Participates in transcription elongation, termination and antitermination.
  
  
 0.572
SCO4660
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
    0.561
SCO5594
tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
   
  
 0.553
SCO2211
Hypothetical protein SC10B7.06; SC10B7.06, unknown, len: 309 aa.
 
    0.543
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.