STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1051SCG20A.31, possible integral membrane protein, len: 357 aa; similar to TR:Q9S290 (EMBL:AL096849) Streptomyces coelicolor putative membrane protein SCI11.29, 354 aa; fasta scores: opt: 422 z-score: 473.8 E(): 6.5e-19; 30.5% identity in 357 aa overlap. (357 aa)    
Predicted Functional Partners:
SCO3927
SCQ11.10c, possible membrane protein, len: 513 aa; unknown function, probable CDS with Pro/Arg-rich N-terminus and 4x degenerate GGGHGA repeats from aa 58-81. Contains hydrophobic, possible membrane-spanning regions.
     
 0.869
SCO4045
2SCD60.11c, possible integral membrane protein, len: 226 aa; similar to TR:O06141 (EMBL:Z95554) Mycobacterium tuberculosis hypothetical 20.4 kDa protein MTCY01B2.16c, 195 aa; fasta scores: opt: 628 z-score: 680.7 E(): 2.4e-30; 50.8% identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions.
     
 0.855
SCO7316
SC5F8.26, possible integral membrane protein, len: 280 aa. Similar to Bacillus subtilis SW:YXXB_BACSU(EMBL:D45912) hypothetical 31.8 kd protein (289 aa), fasta scores opt: 476 z-score: 539.7 E(): 1.4e-22 31.0% identity in 245 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.850
SCO1050
SCG20A.30, possible DNA protection protein, len: 200 aa; similar to SW:DPS_ECOLI (EMBL:X69337) Escherichia coli DNA protection during starvation protein Dps, 166 aa; fasta scores: opt: 200 z-score: 257.4 E(): 7.4e-07; 27.5% identity in 138 aa overlap. Contains Pfam match to entry PF02047 DPS, Dps protein family and matches to Prosite entries PS00818 Dps protein family signature 1 and PS00819 Dps protein family signature 2; Belongs to the Dps family.
       0.820
SCO2735
SCC57A.06, possible integral membrane protein, len: 160 aa. Similar to Streptomyces coelicolor TR:O69999(EMBL:AL022374) putative integral membrane protein SC5B8.13 (174 aa), fasta scores opt: 186 z-score: 231.3 E(): 1.7e-05 34.5% identity in 148 aa overlap. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence.
 
 
   0.748
SCO7602
SC7H9.14, probable tetR-family transcriptional regulator, len: 195 aa; similar to TR:O53323 (EMBL:AL021646) Mycobacterium tuberculosis putative regulatory protein MTV014.17c, 200 aa; fasta scores: opt: 319 z-score: 395.7 E(): 1.7e-14; 33.3% identity in 195 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Also contains possible helix-turn-helix motif at residues 36..57 (+3.70 SD).
 
    0.578
SCO4092
SCD25.28c, ATP-dependent helicase, len: 1327 aa. Highly similar to Escherichia coli SW:HRPA_ECOLI (EMBL; D42105) ATP-dependent helicase (1281 aa), fasta scores opt: 1818 z-score: 1967.4 E(): 0 61.9% identity in 1306 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop).
       0.560
SCO6198
SC2G5.19, possible secreted protein, len: 1156aa; alanine rich, similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores; opt: 2516, z-score: 2119.1, E(): 0, (44.6% identity in 1122 aa overlap). Contains possible N-terminal signal sequence.
  
     0.559
SCO2712
SCC61A.33, possible membrane protein, len: 239aa; weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores; opt: 161, z-score: 172.0, E(): 0.04, 28.4% identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.
     
 0.522
SCO3837
SCH69.07c, putative membrane protein, len: 436 aa. Contains possible hydrophobic membrane spanning regions.
      
 0.520
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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