STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO12352SCG1.10c, ureB, urease beta subunit, len: 103 aa; similar to SW:URE2_RHIME (EMBL:S69145) Rhizobium meliloti urease beta subunit UreB (EC 3.5.1.5), 101 aa; fasta scores: opt: 400 z-score: 525.2 E(): 8.7e-22; 59.8% identity in 102 aa overlap. Contains Pfam match to entry PF00699 Urease_beta, Urease beta subunit. (103 aa)    
Predicted Functional Partners:
SCO1234
2SCG1.09c, ureC, urease alpha subunit, len: 573 aa; similar to SW:URE1_MYCTU (EMBL:L41141) Mycobacterium tuberculosis urease alpha subunit (EC 3.5.1.5) UreC, 577 aa; fasta scores: opt: 2744 z-score: 2925.3 E(): 0; 67.8% identity in 577 aa overlap and to TR:CAA19974 (EMBL:AL031124) Streptomyces coelicolor putative urease alpha subunit SC1C2.07, 558 aa; fasta scores: opt: 1483 z-score: 1444.2 E(): 0; 46.1% identity in 570 aa overlap. Contains Pfam match to entry PF00449 urease, Urease and match to Prosite entry PS01120 Urease nickel ligands signature and PS00145 Urease active site; Belon [...]
 0.999
SCO1236
2SCG1.11c, ureA, urease gamma subunit, len: 100 aa; similar to SW:URE3_MYCTU (EMBL:L41141) Mycobacterium tuberculosis urease gamma subunit (EC 3.5.1.5) UreA, 100 aa; fasta scores: opt: 498 z-score: 638.4 E(): 4.3e-28; 71.7% identity in 99 aa overlap. Contains Pfam match to entry PF00547 urease_gamma, Urease, gamma subunit.
 0.999
SCO5526
SC1C2.07, ureC, probable urease alpha subunit, len: 558 aa; similar to many e.g. URE1_YEREN urease alpha subunit (EC 3.5.1.5) (571 aa), fasta scores; opt: 1676 z-score: 1972.3 E(): 0, 45.2% identity in 564 aa overlap. Contains PS01120 Urease nickel ligands signature and Pfam match to entry PF00449 urease, Urease, score 758.30, E-value 3.3e-224; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
 0.999
SCO1232
Urease accessory protein; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
  
 0.998
SCO1233
Urease accessroy protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.998
SCO5525
SC1C2.06, ureAB, probable fusion of urease beta and gamma subunits, len: 227 aa; N-terminus is similar to UreA e.g. URE3_ECOLI urease gamma subunit (EC 3.5.1.5) (100 aa), fasta scores; opt: 300 z-score: 398.9 E(): 5.7e-15, 44.4% identity in 99 aa overlap; C-terminus is similar to ureB e.g. URE2_YEREN urease beta subunit (EC 3.5.1.5) (163 aa), fasta scores; opt: 303 z-score: 390.6 E(): 1.6e-14, 40.9% identity in 132 aa overlap. This fusion also exists in Helicobacters, where it is called the urease alpha subunit; URE1_HELFE urease alpha subunit (EC 3.5.1.5) (237 aa), fasta scores; opt: [...]
 
0.997
SCO1231
Urease accessory protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.996
SCO6248
SCAH10.13, possible allantoicase, len: 376 aa; similar to SW:ALC_NEUCR (EMBL:J02927) Neurospora crassa allantoicase (EC 3.5.3.4) Alc, 354 aa; fasta scores: opt: 270 z-score: 320.1 E(): 1.9e-10; 35.0% identity in 334 aa overlap; Belongs to the allantoicase family.
    
  0.907
SCO1238
Putative ATP-dependent Clp protease; Has lost one of the conserved residue (Ser) proposed to be part of the active site. Therefore it could be inactive.
     
 0.695
SCO1239
Hypothetical protein 2SCG1.14; 2SCG1.14, unknown, len: 102 aa.
       0.687
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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