STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1244Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (407 aa)    
Predicted Functional Partners:
SCO1246
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.999
SCO1245
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.998
SCO1243
2SCG1.18c, bioF, 8-amino-7-oxononanoate synthase, len: 375 aa; similar to SW:BIOF_BACSH (EMBL:M29291) Bacillus sphaericus 8-amino-7-oxononanoate synthase (EC 2.3.1.47) BioF, 389 aa; fasta scores: opt: 774 z-score: 785.6 E(): 0; 39.1% identity in 379 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
  
 0.983
SCO4927
SCK13.19, probable ligase, len: 291 aa; similar to C-terminal domain of SW:BIRA_ECOLI (EMBL:M10123) Escherichia coli BirA bifunctional protein [includes: biotin operon repressor biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.1) (biotin--protein ligase)], 321 aa; fasta scores: opt: 340 z-score: 382.0 E(): 9.7e-14; 32.7% identity in 260 aa overlap. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase catalytic domain and PF02237 BPL_C, Biotin protein ligase C terminal domain.
  
 
 0.966
SCO6800
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 0.840
SCO5890
SC3F7.10, redN, putative 8-amino-7-oxononanoate synthase, len: 640 aa; similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa), fasta scores; opt: 926 z-score: 888.4 E(): 0, 42.1% identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15, 31.9% identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222, Aminotransferases class-II, score 292.92 in C-terminus.
  
 0.770
SCO5787
Conserved hypothetical protein SC4H2.08; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
     
 0.765
SCO5892
SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...]
 
  
 0.764
SCO1247
2SCG1.22, conserved hypothetical protein, len: 225 aa; similar to TR:O06547 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 23.4 kD protein MTCI65.14, 216 aa; fasta scores: opt: 500 z-score: 599.5 E(): 6.3e-26; 45.9% identity in 209 aa overlap.
  
  
 0.761
SCO3928
Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.705
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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