STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1457SCL6.14c, probable transport protein, len: 413 aa; similar to SW:MALA_BACST (EMBL:L13418) Bacillus stearothermophilus maltose permease MalA, 394 aa; fasta scores: opt: 221 z-score: 243.2 E(): 4e-06; 28.4% identity in 391 aa overlap. Contains possible hydrophobic membrane spanning regions. (413 aa)    
Predicted Functional Partners:
SCO1458
SCL6.15c, probable asnC-family regulatory protein, len: 150 aa; similar to SW:ASNC_HAEIN (EMBL:U32738) Haemophilus influenzae regulatory protein AsnC, 150 aa; fasta scores: opt: 229 z-score: 298.6 E(): 3.3e-09; 28.0% identity in 143 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family and match ot Prostie entry PS00519 Bacterial regulatory proteins, asnC family signature and possible helix-turn-helix motif at residues 19..40 (+3.26 SD).
       0.760
SCO1455
SCL6.12c, possible hydrolase, len: 262 aa; similar to TR:O69808 (EMBL:AL023496) Streptomyces coelicolor putative hydrolase SC1A6.03, 280 aa; fasta scores: opt: 389 z-score: 454.5 E(): 6.8e-18; 31.2% identity in 276 aa overlap. Contains Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase and match to Prosite entry PS01227 Uncharacterized protein family UPF0012 signature.
  
    0.698
SCO1454
SCL6.11c, possible amino oxidase, len: 565 aa; similar to C-terminal region of SW:TR2M_AGRVI (EMBL:M91609) Agrobacterium vitis tryptophan 2-monooxygenase (EC 1.13.12.3) IaaM (auxins biosynthesis), 723 aa; fasta scores: opt: 617 z-score: 725.3 E(): 5.6e-33; 30.9% identity in 557 aa overlap. Contains Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidase.
       0.665
SCO2697
SCC61A.18c, possible secreted protein, len: 192aa; contains a possible cleavable N-terminal signal sequence.
 
     0.548
SCO1456
Hypothetical protein SCL6.13c; SCL6.13c, unknown, len: 119 aa.
       0.539
SCO1459
SCL6.16c, possible amino acid transporter, len: 496 aa; similar to TR:CAB63187 (EMBL:AL133469) Streptomyces coelicolor putative amino acid transporter protein SCM10.26, 468 aa; fasta scores: opt: 1245 z-score: 1366.2 E(): 0; 44.7% identity in 463 aa overlap. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease and possible hydrophobic membrane spanning regions.
       0.476
SCO2962
SCE59.21c, possible bi-functional transferase/deacetylase, len: 734 aa; similar to TR:Q9XAP6 (EMBL:AL078618) Streptomyces coelicolor putative bi-functional transferase/deacetylase SC10A7.29c, 743 aa; fasta scores: opt: 2045 z-score: 2233.4 E(): 0; 59.5% identity in 726 aa overlap and N-terminal region similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) (nodulation protein B) NodB, 217 aa; fasta scores: opt: 411 z-score: 455.6 E(): 5.8e-18; 37.9% identity in 198 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysacch [...]
  
     0.456
SCO4554
SCD16A.29c, possible bi-functional transferase/deacetylase, len: 743aa; 380-620aa region similar to TR:BAA35803 (EMBL:D90739) glycosyl transferase from Escherichia coli (441 aa) fasta scores; opt: 518, z-score: 576.7, E(): 8.6e-25, (35.4% identity in 257 aa overlap). 100-290aa region similar to SW:NODB_RHIME chitooligosaccharide deactylase from Rhizobium meliloti (217 aa) fasta scores; opt: 398, z-score: 448.0, E(): 1.3e-17, (35.7% identity in 196 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Also contains possible membrane spanning hydrophob [...]
  
     0.443
SCO0826
SCF43A.16, hypothetical protein, len: 266 aa; unknown function, shares short internal regions of similarity with several methyltransferases e.g. TR:O82434 (EMBL:AF053766) Nicotiana tabacum S-adenosyl-methionine cycloartenol-C24-methyltransferase (349 aa), fasta scores; opt: 165 z-score: 206.0 E(): 0.00038, 29.8% identity in 104 aa overlap. Weakly similar to part of SC1E6.19C (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.1% identity in 131 aa overlap).
  
     0.414
SCO1461
SCL6.18c, guaB2, probable inosine monophosphate dehydrogenase, len: 483 aa; similar to SW:IMDH_BACSU (EMBL:X55669) Bacillus subtilis inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) GuaB, 513 aa; fasta scores: opt: 970 z-score: 1018.4 E(): 0; 37.4% identity in 471 aa overlap. Contains Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus, two matches to entry PF00571 CBS, CBS domain and to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus.
     
 0.408
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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