STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1459SCL6.16c, possible amino acid transporter, len: 496 aa; similar to TR:CAB63187 (EMBL:AL133469) Streptomyces coelicolor putative amino acid transporter protein SCM10.26, 468 aa; fasta scores: opt: 1245 z-score: 1366.2 E(): 0; 44.7% identity in 463 aa overlap. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease and possible hydrophobic membrane spanning regions. (496 aa)    
Predicted Functional Partners:
SCO1458
SCL6.15c, probable asnC-family regulatory protein, len: 150 aa; similar to SW:ASNC_HAEIN (EMBL:U32738) Haemophilus influenzae regulatory protein AsnC, 150 aa; fasta scores: opt: 229 z-score: 298.6 E(): 3.3e-09; 28.0% identity in 143 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg, AsnC family and match ot Prostie entry PS00519 Bacterial regulatory proteins, asnC family signature and possible helix-turn-helix motif at residues 19..40 (+3.26 SD).
  
    0.768
SCO1859
SCI39.06, probable aminotransferase, len: 339 aa; similar to SW:HIS8_ECOLI (EMBL:X03416) Escherichia coli histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC, 356 aa; fasta scores: opt: 351 Z-score: 375.7 bits: 78.0 E(): 2.4e-13; 29.450% identity in 309 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferase class-II and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
      
 0.648
SCO3944
Putative histidinol-phophate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
      
 0.648
SCO5257
Methyltransferase; 2SC7G11.19, metZ, methyltransferase, len: 269 aa; previously sequenced as TR:Q9RGW5 (EMBL:AF104994) Streptomyces coelicolor A3(2) methyltransferase MetZ, 268 aa.
      
 0.519
SCO2640
Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
   
 
 0.512
SCO3614
Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
   
 
 0.512
SCO2012
SC7H2.26, probable branched chain amino acid transport ATP-binding protein, len: 238aa; similar to many eg. SW:LIVF_ECOLI branched chain amino acid transport ATP-binding protein from Escherichia coli (237 aa) fasta scores; opt: 774, z-score: 860.8, E(): 0, (52.4% identity in 233 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
      
 0.505
SCO2905
Hypothetical protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine (GlcNAc) transport.
      
 0.494
SCO6007
Probable transmembrane transport protein; Part of the ABC transporter complex NgcEFG-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family.
      
 0.483
SCO1457
SCL6.14c, probable transport protein, len: 413 aa; similar to SW:MALA_BACST (EMBL:L13418) Bacillus stearothermophilus maltose permease MalA, 394 aa; fasta scores: opt: 221 z-score: 243.2 E(): 4e-06; 28.4% identity in 391 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.476
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.