STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1496Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)    
Predicted Functional Partners:
SCO1494
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
 
  
 0.999
SCO1495
Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.997
SCO5212
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.991
SCO6819
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.991
SCO1498
SC9C5.22c, aroE, shikimate 5-dehydrogenase, len: 255 aa; similar to SW:AROE_PSEAE (EMBL:X85015) Pseudomonas aeruginosa shikimate 5-dehydrogenase (EC 1.1.1.25) AroE, 274 aa; fasta scores: opt: 294 z-score: 335.8 E(): 3.1e-11; 31.3% identity in 259 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase.
 
  
 0.990
SCO2043
Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...]
 
 
 0.988
SCO3214
Probable anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...]
 
 
 0.985
SCO2019
SC7H2.33c, possible chorismate mutase, len: 116aa; similar to the N-terminal region (which has been shown to contain chorismate mutase activity) of SW:TYRA_ERWHE T-protein chorismate mutase/chorismate dehydrogenase bifunctional protein from Erwinia herbicola (373 aa) fasta scores; opt: 179, z-score: 228.0, E(): 2.2e-05, (38.5% identity in 78 aa overlap).
  
 
 0.972
SCO4784
SCD63.16c, hypothetical protein, len: 110 aa; similar to SW:Y948_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 11.8 kD protein RV0984c, MTCY10D7.26, 105 aa; fasta scores: opt: 195 z-score: 252.8 E(): 1.2e-06; 47.2% identity in 72 aa overlap.
  
 
 0.972
SCO1761
SCI51.01c, possible cyclohexadienyl dehydrogenase, partial CDS, len: >212 aa; similar to several cyclohexadienyl dehydrogenases e.g. SW:TYRC_ZYMMO (EMBL:M75891), TyrC, Zymomonas mobilis cyclohexadienyl dehydrogenase (293 aa), fasta scores; opt: 299 z-score: 344.0 E(): 7.8e-12, 31.4% identity in 220 aa overlap. Also similar to other hypothetical oxidoreductases e.g. CZA382.29 (EMBL:AL078635) Streptomyces coelicolor putative oxidoreductase (367 aa) (55.8% identity in 208 aa overlap); 2SCI34.14c, possible oxidoreductase (fragment) (putative secreted protein), len: >182 aa; similar to TR:Q [...]
 
 
 0.968
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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