STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1553SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...] (410 aa)    
Predicted Functional Partners:
SCO1858
SCI39.05, conserved hypothetical protein, len: 305 aa; similar to TR:O87690 (EMBL:AJ000758) Bacillus megaterium Cbi protein CbiX, 306 aa; fasta scores: opt: 791 Z-score: 870.2 bits: 169.1 E(): 7e-41; 39.000% identity in 300 aa overlap. Contains Pfam match to entry PF01903 CbiX, CbiX.
 
 0.998
SCO3317
SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...]
 
 
0.997
SCO6102
SCBAC1A6.26c, probable nitrite/sulphite reductase, len: 565 aa; similar to SW:NIR_SYNP7 (EMBL:D12723) Synechococcus sp. ferredoxin--nitrite reductase (EC 1.7.7.1) NirA, 512 aa; fasta scores: opt: 935 z-score: 1113.1 E(): 0; 35.6% identity in 525 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase 4Fe-4S domain.
 
  
 0.992
SCO7343
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.992
SCO3318
Putative porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.990
SCO1853
SCI8.38, cobI, precorrin-2 C20-methyltransferase (EC 2.1.1.130), len: 243 aa. Similar to many including: Pseudomonas denitrificans SW:COBI_PSEDE (EMBL: M59301) precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine-precorrin-2 methyltransferase) (SP2MT) (244 aa), fasta scores opt: 322 z-score: 369.3 E(): 3.3e-13 30.0% identity in 240 aa overlap and to the N-terminus of the CobI/J fusion protein from Mycobacterium tuberculosis SW:COBI_MYCTU (EMBL: Z73966) cobalamin biosynthesis protein CobIJ [includes: precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-met [...]
 
 
 0.985
SCO2958
SCE59.17c, possible transcriptional regulator, len: 395 aa; similar to TR:P95217 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 40.7 kD protein MCTY0A4.04c, 381 aa; fasta scores: opt: 1224 z-score: 1335.3 E(): 0; 52.3% identity in 377 aa overlap and C-terminal region similar to SW:CUTR_STRCO (EMBL:X58793) Streptomyces coelicolor transcriptional regulatory protein CutR, 217 aa; fasta scores: opt: 130 z-score: 151.1 E(): 0.53; 30.3% identity in 132 aa overlap. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
 
 0.985
SCO1554
Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
 
  
 0.982
SCO2471
SC7A8.10c, possible secreted protein, len: 274 aa; similar to various hypothetical proteins, e.g. TR:P95216 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 26.2 kD protein, 247 aa; fasta scores: opt:413 z-score: 450.1 E(): 1.1e-17; 34.5% identity in 232 aa overlap. Contains possible N-terminal region signal peptide sequence.
  
 0.976
SCO6099
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
 
  
 0.969
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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