STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1567SCL24.03c, possible transmembrane-transport protein, len: 510 aa; similar to TR:O33968 (EMBL:U80063) Streptomyces cinnamoneus putative transmembrane, proton-dependent transport protein, 519 aa; fasta scores: opt: 2339 z-score: 2439.5 E(): 0; 72.7% identity in 510 aa overlap and to SW:QACA_STAAU (EMBL:X56628) Staphylococcus aureus antiseptic resistance protein QacA, 514 aa; fasta scores: opt: 1116 z-score: 1166.8 E(): 0; 36.6% identity in 503 aa overlap. Contains possible hydrophobic membrane spanning regions. (510 aa)    
Predicted Functional Partners:
SCO1568
SCL24.04c, probable tetR-family transcriptional regulator, len: 189 aa; similar to SW:NFXB_PSEAE (EMBL:X65646) Pseudomonas aeruginosa transcriptional regulatory protein NfxB, 187 aa; fasta scores: opt: 297 z-score: 367.8 E(): 4.5e-13; 33.3% identity in 174 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Contains also possible helix-turn-helix motif at residues 28..49 (+5.21 SD).
 
  
 0.931
SCO1570
SCL24.06c, argH, argininosuccinate lyase, len: 475 aa; highly similar to SW:ARLY_CORGL (EMBL:AF049897) Corynebacterium glutamicum argininosuccinate lyase (EC 4.3.2.1) ArgH, 478 aa; fasta scores: opt: 1473 z-score: 1658.6 E(): 0; 59.1% identity in 391 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and two matches to Prosite entries PS00163 Fumarate lyases signature and PS00017 ATP/GTP-binding site motif A (P-loop).
     
 0.663
SCO1569
SCL24.05c, possible oxidoreductase, len: 350 aa; similar to TR:AAF09836 (EMBL:AE001886) Deinococcus radiodurans oxidoreductase, putative DR0249, 357 aa; fasta scores: opt: 1019 z-score: 1133.1 E(): 0; 51.0% identity in 359 aa overlap.
       0.545
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.