STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1596SCI35.18c, probable two-component sensor, len: 379 aa; similar to many e.g. HYDH_ECOLI sensor protein hydH (465 aa), fasta scores; opt: 296 z-score: 418.4 E(): 4.6e-16, 35.4% identity in 257 aa overlap. No apparent transmembrane domains. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, score 205.10, E-value 1e-57. (379 aa)    
Predicted Functional Partners:
SCO5749
SC7C7.04, probable two-component regulator, len: 224 aa; similar to many e.g. PHOB_ECOLI phosphate regulon transcriptional regulator (229 aa), fasta scores; opt: 200 z-score: 349.0 E(): 3.3e-12, 28.2% identity in 216 aa overlap. Contains probable coiled-coil from 153 to 195 and Pfam match to entry response_reg PF00072, Response regulator receiver domain, score 125.68.
     0.932
SCO3008
SCE33.10c, probable two-component system response regulator, len: 252 aa; similar to TR:AAF10563 (EMBL:AE001951) Deinococcus radiodurans DNA-binding response regulator DR0987, 239 aa; fasta scores: opt: 576 z-score: 658.2 E(): 3.3e-29; 44.0% identity in 218 aa overlap and to various Streptomyces coelicolor putative two-component response regulators, e.g. TR:CAB59507 (EMBL:AL132648) SCI41.37, 223 aa; fasta scores: opt: 622 z-score: 571.0 E(): 2.8e-26; 47.2% identity in 214 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00196 G [...]
 
 
 
 0.856
SCO5351
SCBAC5H2.20, possible regulatory protein, len: 167 aa; similar to the N-terminal domain of several regulatory proteins, e.g. TR:Q9X6C1 (EMBL:AF135389) Tolypothrix PCC7601 DNA binding response regulator RpaA, 247 aa; fasta scores: opt: 332 z-score: 343.7 E(): 1.4e-11; 42.0% identity in 119 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain.
 
 
 0.826
SCO1597
SCI35.19c, probable rRNA methylase, len: 282 aa; similar to many members of ther spoU famil e.g. TSNR_STRLU 23s rRNA methyltransferase (270 aa), fasta scores; opt: 254 z-score: 251.7 E(): 9e-07, 27.0% identity in 270 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 107.90, E-value 1.9e-28; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
       0.815
SCO3063
SCE25.04c, probable two-component system reponse regulator, len: 225 aa; similar to TR:CAB77324 (EMBL:AL160331) Streptomyces coelicolor putative response regulator SCD8A.03, 223 aa; fasta scores: opt: 688 z-score: 781.9 E(): 0; 48.9% identity in 223 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
 0.800
SCO3716
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
  
  
 0.784
SCO4907
Transcriptional regulatory protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.
 
 0.763
SCO3013
SCE33.15c, probable two-component system response regulator, len: 229 aa; similar to TR:Q50447 (EMBL:Z95121) Mycobacterium tuberculosis MtrA, 228 aa; fasta scores: opt: 1141 z-score: 1397.7 E(): 0; 74.9% identity in 227 aa overlap, to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1, 225 aa; fasta scores: opt: 698 z-score: 858.5 E(): 0; 47.7% identity in 220 aa overlap and to many other S. coelicolor two-component system response regulators, e.g. TR: CAB77324(EMBL:AL160331) putative response regulator SCD8A.03, 223 aa; fasta scores: opt: 695 [...]
 
 0.754
SCO7533
SC8G12.09, two-component system response regulator protein, len: 233 aa. Highly similar to many putative response regulators including: Amycolatopsis mediterranei TR:CAB82846(EMBL:AJ277082) putative response regulator (229 aa), fasta scores opt: 937 z-score: 1114.4 E(): 0 61.9% identity in 231 aa overlap and Streptomyces coelicolor TR:Q9ZEP4(EMBL:AJ131213) response regulator, SCE94.09 (234 aa), fasta scores opt: 665 z-score: 793.6 E():0 45.5% identity in 231 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and a Pfam match to entry PF0 [...]
 
 0.751
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
       0.750
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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