STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1607SCI35.29c, probable serine protease (putative membrane protein), len: 393 aa; similar to many members of the subtilase family e.g. SUBT_BACLI subtilisin carlsberg precursor (379 aa), fasta scores; opt: 377 z-score: 509.5 E(): 3.9e-21, 38.8% identity in 276 aa overlap. Contains probable possible hydrophobic membrane spanning regions (one possible hydrophobic span at the N-terminal region and another one at the C-terminal region), PS00136 Serine proteases, subtilase family, aspartic acid active sitea and Pfam match to entry PF00082 subtilase, Subtilase family of serine proteases, score 1 [...] (393 aa)    
Predicted Functional Partners:
SCO1608
Hypothetical protein SCI35.30c; SCI35.30c, unknown, len: 237 aa; start uncertain, may be considerably further upstream.
       0.875
SCO4508
SCD35.15, possible cell division-related protein, len: 1525 aa; similar to TR:P71068 (EMBL:Z99120) Bacillus subtilis YukA protein, 1207 aa; fasta scores: opt: 682 z-score: 717.6 E(): 1.5e-32; 23.7% identity in 1288 aa overlap and C-terminal region similar to TR:O25722 (EMBL:AE000615) Helicobacter pylori (Campylobacter pylori) cell division protein (FtsK), 858 aa; fasta scores: opt: 347 z-score: 364.2 E(): 7.4e-13; 33.1% identity in 245 aa overlap. Contains two Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family and match to Prosite entry PS00017 ATP/GTP-binding site motif A [...]
  
 
 0.656
SCO5734
SC3C3.20c, unknown ATP/GTP binding protein (putative membrane protein), len: 1321 aa; similar to several in M. tuberculosis and M. leprae e.g. M. tuberculosis TR:O06264 (EMBL:Z95389) MTCY77.19c, Rv3447c (1236 aa), fasta scores; opt: 1186 z-score: 3117.9 E(): 0, 42.9% identity in 1312 aa overlap. Contains 3x, PS00017 ATP /GTP-binding site motif A (P-loop), and a possible transmembrane domain near the C-terminus.
  
 
 0.656
SCO1602
Hypothetical protein SCI35.24c; SCI35.24c, unknown, len: 243 aa; possible truncated at N-terminus by IS117.
       0.560
SCO1609
SCI35.31, unknown, len: 402 aa; similar to a hypothetical protein from M. tuberculosis TR:O06802 (EMBL:Z95890) MTCY28.35 (414 aa), fasta scores; opt: 1341 z-score: 1649.4 E(): 0, 53.8% identity in 398 aa overlap.
       0.560
SCO2499
SCC121.02c, possible transport ATPase, len: 1472 aa; similar to TR:P96271 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 159.8 kD protein MTCY22G10.22c, 1539 aa; fasta scores: opt: 2216 z-score: 2157.1 E(): 0; 38.4% identity in 1543 aa overlap and N-terminal region similar to SW:ATMA_SALTY (EMBL:U07843) Salmonella typhimurium Mg(2+) transport atpase, P-type 1 (EC 3.6.1.-) MgtA, 902 aa; fasta scores: opt: 800 z-score: 779.8 E(): 0; 28.0% identity in 880 aa overlap. Contains Pfam match to entry PF00122 E1-E2_ATPase, match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site [...]
  
 0.435
SCO4332
SCD12A.15c, possible integral membrane ATPase, len: 802 aa; similar to TR:Q9Z4W5 (EMBL:AL035654) Streptomyces coelicolor putative integral membrane ATPase SCE8.09, 796 aa; fasta scores: opt: 3320 z-score: 3591.6 E(): 0; 67.0% identity in 796 aa overlap and to TR:O93862 (EMBL:AF043332) Aspergillus nidulans plasma membrane H(+)ATPase PmaA, 990 aa; fasta scores: opt: 504 z-score: 543.3 E(): 8.4e-23; 25.4% identity in 808 aa overlap. Contains 2x Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase and match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site. Contains also possib [...]
  
 0.415
SCO3216
SCE8.09, probable integral membrane ATPase, len: 796 aa; member of a large family including SW:Y1B2_MYCTU putative cation-transporting ATPase from Mycobacterium tuberculosis (797 aa) fasta scores; opt: 2741, z-score: 2896.9, E(): 0, (56.8% identity in 791 aa overlap). Contains two Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPases, score 109.40, E-value 9.7e-30 and score 155.80, E-value 7.3e-43, and Prosite match to PS00154 E1-E2 ATPases phosphorylation site.
  
 0.413
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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