STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1616SCI35.38c, probable transcriptional regulator, len: 325 aa; similar to many members of the lysR family CBBR_RHORU RUBISCO operon transcriptional regulator (298 aa), fasta scores; opt: 394 z-score: 410.2 E(): 1.3e-15, 30.2% identity in 295 aa overlap. Contains PS00044 Bacterial regulatory proteins, lysR family signature, possible helix-turn-helix motif at aa 53-74 (Score 1391, +3.92 SD), and Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix proteins, lysR family, score 129.30, E-value 7e-35. (325 aa)    
Predicted Functional Partners:
SCO1617
SCI35.39, probable integral membrane protein, len: 394 aa; similar to several hypothetical membrane proteins e.g. Rhodococcus erythropolis TR:O07448 (EMBL:AF002247) (295 aa), fasta scores; opt: 868 z-score: 961.0 E(): 0, 44.9% identity in 292 aa overlap.
 
     0.774
SCO3435
SCE36.02, probable transcriptional regulator, len: 295 aa; similar to many e.g. SW:GLTC_BACSU glutamate biosynthesis transcriptional regulator from Bacillus subtilis (300 aa) fasta scores; opt: 456, z-score: 520.3, E(): 1.2e-21, (31.9% identity in 288 aa overlap). Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix proteins, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.
  
     0.737
SCO7025
SC1H10.14c, probable LysR-family transcriptional regulator, len: 305 aa. Highly similar to the Streptomyces lividans TR:Q9ZI19 (EMBL:AF043654) putative LysR-type of transcriptional regulator, BxlS (300 aa), fasta scores opt: 1743 z-score: 1937.0 E(): 0 91.0% identity in 300 aa overlap. Also similar to many other putative LysR-family transcriptional regulators e.g. Streptomyces coelicolor TR:O86805 (EMBL:AL031317) putative transcriptional regulator, SC6G4.44 (306 aa), fasta scores opt: 479 z-score: 538.0 E(): 1.5e-22 38.3% identity in 300 aa overlap. Contains a Prosite hit to PS00044 Ba [...]
  
     0.713
SCO4482
SCD69.02c, probable lysR-family transcriptional regulator, len: 286 aa; similar to TR:CAB55655 (EMBL:AL117385) Streptomyces coelicolor putative lysR-family transcriptional regulator SC5G9.07c, 287 aa; fasta scores: opt: 495 z-score: 551.1 E(): 3.1e-23; 37.0% identity in 297 aa overlap and to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis als operon regulatory protein AlsR, 302 aa; fasta scores: opt: 390 z-score: 435.8 E(): 8.2e-17; 32.1% identity in 293 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and match to Prosite [...]
  
     0.697
SCO0089
SCJ11.18, probable LysR-family transcriptional regulator, len: 345 aa; similar to many e.g. SW:ALSR_BACSU ALS operon regulator from Bacillus subtilis (302 aa) fasta scores; opt: 507, z-score: 564.5, E(): 4.4e-24, (31.0% identity in 290 aa overlap). Note possible alternative start codons downstream. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.
  
     0.693
SCO4434
SCD6.12, probable LysR-family transcriptional regulator, len: 298 aa; similar to TR:Q9X9U9 (EMBL:Y18817) Streptomyces coelicolor A3(2) transcriptional regulator of LysR family, 307 aa; fasta scores: opt: 736 z-score: 859.4 E(): 0; 43.6% identity in 303 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, match to Prosite entry PS00044 Bacterial regulatory proteins, lysR family signature and possible helix-turn-helix motif at residues 18..39 (+4.94 SD).
  
     0.682
SCO6801
SC1A2.10, possible LysR-family transcriptional regulator, len: 300 aa. Similar to many other regulators e.g. Streptomyces coelicolor TR:CAB62680 (EMBL:AL133422) putative LysR-family transcriptional regulatory protein, SCM1.22C (301 aa), fasta scores opt: 673 z-score: 751.5 E():0 40.3% identity in 300 aa overlap. Contains 2x Prosite hits to PS00044 Bacterial regulatory proteins, lysR family signature and a Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family with the putative helix-turn-helix motif situated between residues 17..38 (+4.44 SD).
  
     0.678
SCO2964
SCE59.23c, probable lysR-family transcriptional regulator, len: 323 aa; similar to TR:O88132 (EMBL:AJ006517) Streptomyces lipmanii lysR-type transcriptional regulator StgR, 327 aa; fasta scores: opt: 551 z-score: 619.3 E(): 4.4e-27; 36.6% identity in 320 aa overlap and to SW:XAPR_ECOLI (EMBL:X63976) Escherichia coli xanthosine operon regulatory protein XapR, 294 aa; fasta scores: opt: 364 z-score: 412.4 E(): 1.5e-15; 33.6% identity in 301 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and match to Prosite entry PS00044 [...]
  
     0.657
SCO7433
Small neutral protease regulatory protein; Transcriptional trans-activator of the gene (mprA) for the small neutral protease.
  
     0.618
SCO0927
SCM10.15, probable lysR-family transcriptional regulator, len: 278 aa; similar to TR:CAB55655 (EMBL:AL117385) Streptomyces coelicolor putative lysR-family transcriptional regulator SC5G9.07c, 287 aa; fasta scores: opt: 598 z-score: 666.9 E(): 9.3e-30; 47.9% identity in 286 aa overlap and to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis ALS operon regulatory protein AlsR, 302 aa; fasta scores: opt: 398 z-score: 446.6 E(): 1.7e-17; 37.6% identity in 186 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and two mathces to Pr [...]
  
     0.604
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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