STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1633Putative secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (95 aa)    
Predicted Functional Partners:
SCO1632
Putative integral membrane protein SCI41.15c; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
 
 0.999
SCO5150
Putative membrane protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
    
 0.986
SCO4722
Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
   
 0.903
SCO3768
SCH63.15, possible translocase protein, len: 82 aa; similar to SW:YK94_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis hypothetical 8.9 kDa protein MTCY49.34c, 83 aa; fasta scores: opt: 123 z-score: 165.1 E(): 0.11; 40.6% identity in 69 aa overlap. Contains Pfam match to entry PF02416 MttA_Hcf106.
     
 
0.900
SCO3005
Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
      
 0.899
SCO4785
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.875
SCO5580
Putative prokaryotic docking protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
   
  
 0.800
SCO1631
SCI41.14c, possible helicase, len: 950 aa. Similar to TR:O69801 (EMBL:AJ223310) Streptomyces avermitilis SAB3 helicase, 612 aa; fasta scores: opt: 2382 z-score: 2658.3 E(): 0; 68.9% identity in 602 aa overlap. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase and PS00017 ATP/GTP-binding site motif A (P-loop). Contains probable coiled-coil from 554 to 586 (33 residues, max score: 1.477, probability 0.92).
       0.760
SCO1636
SCI41.19c, unknown, len: 360 aa. Similar to various hypothetical proteins, e.g. TR:P72265 (EMBL:Z82004) Rhodococcus erythropolis ORF11, 326 aa; fasta scores: opt: 694 z-score: 768.9 E(): 0; 39.8% identity in 322 aa overlap.
  
  
 0.746
SCO1637
SCI41.20c, unknown, len: 317 aa. Similar to various hypothetical proteins, e.g. TR:P72264 (EMBL:Z82004) Rhodococcus erythropolis ORF10, 330 aa; fasta scores: opt: 578 z-score: 682.7 E(): 1.2e-30; 39.5% identity in 332 aa overlap.
  
  
 0.740
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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