STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
SCO1658Glycerol operon regulatory protein; May be an activator protein for the gylABX operon. (254 aa)    
Predicted Functional Partners:
SCO1659
Putative glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family.
     
 0.830
SCO1660
Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
     
 0.786
SCO0345
SCF41.04c, probable IclR family regulator (putative secreted protein), len: 260 aa. Similar to many e.g. Agrobacterium tumefaciens TR:AAD43987 (EMBL:U59485) AttJ (275 aa), fasta scores: opt: 354 z-score: 406.3 E(): 2.8e-15 31.6% identity in 237 aa overlap and Streptomyces coelicolor TR:CAB45040 (EMBL:AL078635) putative transcriptional regulator (248 aa), fasta scores: opt: 333 z-score: 383.3 E(): 5.3e-14 32.3% identity in 248 aa overlap. Contains a Pfam match to entry PF01614 IclR.
  
     0.771
SCO4849
SC5G8.17, possible integral membrane protein, len: 436 aa; N-terminal region contains possible membrane-spanning hydrophobic regions while the remainder is similar to many hypothetical proteins e.g. TR:Q9ZM43 (EMBL:AE001473) putative from Helicobacter pylori J99 (370 aa) fasta scores; opt: 596, z-score: 590.7, E(): 1.9e-25, 37.4% identity in 273 aa overlap.
      
 0.770
SCO2832
SCE20.06, possible IclR-family transcriptional regulator, len: 285 aa, Almost identical to a gene fragment which, like SCE20.06, is located upstream of the Streptomyces lividans lysT tRNA gene: TR:Q54411(EMBL:X52073) (200 aa), fasta scores opt: 1250 z-score: 1464.9 E():0 99.5% identity in 200 aa overlap. Also similar to Streptomyces coelicolor TR:Q9X9U3(EMBL:AL096823) putative transcriptional regulator (241 aa), fasta scores opt: 597 z-score: 704.2 E(): 7.7e-32 43.2% identity in 236 aa overlap. Contains a Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator with a puta [...]
  
     0.704
SCO2935
SCE19A.35c, probable transcriptional regulator, len: 220 aa; similar to many e.g. SW:ICLR_ECOLI (EMBL:M31761), IclR, Escherichia coli acetate operon repressor (274 aa), fasta scores; opt: 206 z-score: 234.8 E(): 9.6e-06, 29.2% identity in 154 aa overlap. Similar to TR:O05148 (EMBL:U89712), hppR, Rhodococcus globerulus putative regulator of 3-(3-hydroxyphenyl)propionic acid catabolic pathway (206 aa) (44.8% identity in 174 aa overlap). Contains probable helix-turn-helix motif at aa 27-48 (Score 1663, +4.85 SD).
  
     0.699
SCO1661
SCI52.03, probable glycerol-3-phosphate dehydrogenase, len: 538 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39; 30.830% identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase.
       0.677
SCO7295
Putative LuxR-family regulator; SC5F8.05c, possible LuxR-family regulator, len: 988 aa. Similar to several other putative regulators from Streptomyces coelicolor including: TR:Q9XAN4 (EMBL:AL079355) SC4C6.06 (893 aa), fasta scores opt: 305 z-score: 328.7 E(): 7.7e-11 26.4% identity in 910 aa overlap and TR:Q9Z573 (EMBL:AL035569) SC8D9.18 (1091 aa), fasta scores opt: 857 z-score: 926.1 E(): 0 36.5% identity in 1077 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family.
   
  
 0.671
SCO7613
SC2H2.11c, possible integral membrane protein, len: 818 aa. Contains possible hydrophobic membrane spanning regions and 4x degenerate repeat unit: SRTGG.
   
  
 0.669
SCO0745
SCF81.04c, possible tetR-family transcriptional regulator, len: 219 aa; similar to various Streptomyces transcriptional regulators, e.g. TR:Q9ZBK0 (EMBL:AL035161) Streptomyces coelicolor putative transcriptional regulator SC9C7.10c, 272 aa; fasta scores: opt: 189 z-score: 243.3 E(): 3.5e-06; 29.8% identity in 218 aa overlap. Contains match to Pfam entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
      
 0.667
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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