STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1663Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins. (409 aa)    
Predicted Functional Partners:
SCO5126
Conserved hypothetical protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway; Belongs to the MshB deacetylase family.
 
  
 0.986
SCO4204
Putative glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway; Belongs to the glycosyltransferase group 1 family. MshA subfamily.
  
   
 0.960
SCO4967
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
 
  
 0.942
SCO4151
Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subfamily.
 
   
 0.940
SCO1664
SCI52.06, conserved hypothetical protein, len: 265 aa; similar to TR:O06242 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 28.3 kDa protein MTCY270.35, 262 aa; fasta scores: opt: 495 Z-score: 595.6 bits: 117.9 E(): 1.4e-25; 50.951% identity in 263 aa overlap.
 
   
 0.919
SCO1665
SCI52.07c, conserved hypothetical protein, len: 196 aa; similar to TR:O06241 (EMBL:Z95388)Mycobacterium tuberculosis hypothetical 21.2 kDa protein MTCY270.34, 195 aa; fasta scores: opt: 409 Z-score: 445.1 bits: 89.2 E(): 3.3e-17; 54.639% identity in 194 aa overlap.
 
     0.860
SCO5438
Thioredoxin; SC6A11.14, trxA2, thioredoxin, len: 104 aa; similar to many e.g. SW:P52230 (THIO_STRCO) thioredoxin TrxA from Streptomyces coelicolor (110 aa) fasta scores: opt: 360, z-score: 470.8, E(): 8.2e-19, 47.5% identity in 101 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin and Prosite match to PS00194 Thioredoxin family active site; Belongs to the thioredoxin family.
   
  
 0.785
SCO1666
SCI52.08c, possible phosphatase, len: 228 aa; similar to SW:COBC_ECOLI (EMBL:U23163) Escherichia coli alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.*) CobC or PhpB or B0638, aa; fasta scores: opt: 212 Z-score: 252.7 bits: 53.8 E(): 1.7e-06; 29.412% identity in 187 aa overlap and to TR:O06240 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 21.5 kDa protein MTCY270.33, 250 aa; fasta scores: opt: 725 Z-score: 836.0 bits: 162.0 E(): 5.5e-39; 51.923% identity in 208 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.
 
     0.775
SCO0885
Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).
   
  
 0.754
SCO2137
Hypothetical protein; SC6G10.10c, unknown, len: 447aa; some similarity to TR:Q60218 (EMBL:L10330) TraN from plasmid RP4 of Escherichia coli (261 aa) fasta scores; opt: 176, z-score: 185.4, E(): 0.005, (29.5% identity in 224 aa overlap). Contains probable coiled coil region.
  
    0.754
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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