STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1683SCI30A.04c, possible amino acid permease, len: 512 aa; similar to many e.g. TR:Q53148 (EMBL:L24492) ethanolamine permease from Rhodococcus sp. strain NI86/21 (488 aa) fasta scores; opt: 266, z-score: 293.8, E(): 4.9e-09, (26.7% identity in 397 aa overlap). Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains possible membrane spanning hydrophobic regions. (512 aa)    
Predicted Functional Partners:
SCO1686
SCI30A.07, possible NTP pyrophosphohydrolase, len: 181 aa; similar to many e.g. TR:Q53738 (EMBL:X92429) from the puromycin biosynthetic pathway of Streptomyces alboniger (152 aa) fasta scores; opt: 170, z-score: 226.2, E(): 2.9e-05, (35.7% identity in 129 aa overlap). Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein.
     
 0.702
SCO7785
SC5E9.33, possible transcriptional regulator, len: 206 aa; weakly similar to many eg. TR:Q9S250 (EMBL:AL096811) putative transcriptional regulator from Streptomyces coelicolor (213 aa) fasta scores; opt: 159, z-score: 199.4, E(): 0.0012, 25.7% identity in 171 aa overlap. Contains helix-turn-helix motif (Score 1164 (+3.15 SD)) at residue 33-54. Note possible alternative downstream start sites.
 
     0.678
SCO1778
SCI51.18, possible transcriptional regulator, len: 548 aa; shows weak similarity to TR:Q00509 (EMBL:X63451), SmrR, Streptomyces ambofaciens regulatory gene governing the expression of a polyketide synthase (604 aa), fasta scores; opt: 205 z-score: 220.9 E(): 5.9e-05, 26.5% identity in 460 aa overlap. Also similar to TR:O69807 (EMBL:AL023496) Streptomyces coelicolor hypothetical protein (537 aa) (32.4% identity in 547 aa overlap) and PkwR (EMBL:AF115313) Thermomonospora curvata putative regulatory protein (535 aa) (28.8% identity in 534 aa overlap). Contains probable helix-turn-helix mo [...]
 
     0.674
SCO1684
Hypothetical protein; SCI30A.05c, unknown, len: 338aa.
       0.668
SCO1687
SCI30A.08, putative membrane protein, len: 130 aa; similar to SW:YIDH_ECOLI hypothetical protein from Escherichia coli (115 aa) fasta scores; opt: 291, z-score: 382.3, E(): 5.8e-14, (47.3% identity in 112 aa overlap). Contains possible hydrophobic membrane spanning regions.
       0.530
SCO1685
SCI30A.06, possible integral membrane protein, len: 297aa; similar to many egs. TR:O33234 (EMBL:Z98209) hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores; opt: 356, z-score: 407.0, E(): 2.4e-15, (31.5% identity in 289 aa overlap) and TR:O86668 (EMBL:AL031182) putative integral membrane protein from Streptomyces coelicolor (299 aa) fasta scores; opt: 272, z-score: 312.9, E(): 4.2e-10, (31.5% identity in 279 aa overlap).
 
 
   0.516
SCO5678
SC5H4.02, possible regulatory protein, len: 552 aa; similar to TR:Q9ZBP0 (EMBL:AL034492) Streptomyces coelicolor putative regulatory protein SC6C5.05c, 569 aa; fasta scores: opt: 310 z-score: 323.3 E(): 1.5e-10; 30.0% identity in 587 aa overlap.
 
     0.441
SCO6413
SC1A6.02, possible DNA-binding protein, len: 537 aa; some similarity to a regulator of polyketide gene expression from Streptomyces ambofaciens; TR:Q00509 (EMBL:X63451) srmR (604 aa), fasta scores; opt: 160 z-score: 215.6 E(): 7e-05, 26.8% identity in 400 aa overlap. Contains probable helix-turn-helix motifat aa 486-507 (Score 1520, +4.36 SD).
 
     0.439
SCO2770
Agmatinase; SCC105.01c, speB, agmatinase (fragment), len: >302 aa; highly similar to N-terminal region of SW:SPEB_STRCL (EMBL:L15470) Streptomyces clavuligerus possible agmatinase (EC 3.5.3.11) Pah, 313 aa; fasta scores: opt: 843 z-score: 968.6 E(): 0; 43.3% identity in 293 aa overlap and of SW:SPEB_ECOLI (EMBL:M32363) Escherichia coli agmatinase (EC 3.5.3.11), SpeB, 306 aa; fasta scores: opt: 473 z-score: 546.7 E(): 5.1e-23; 41.8% identity in 282 aa overlap. Contains Pfam match to entry PF00491 arginase, Arginase family and matches to Prosite entries PS00147 Arginase family signature [...]
 
  
 0.402
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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