STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1686SCI30A.07, possible NTP pyrophosphohydrolase, len: 181 aa; similar to many e.g. TR:Q53738 (EMBL:X92429) from the puromycin biosynthetic pathway of Streptomyces alboniger (152 aa) fasta scores; opt: 170, z-score: 226.2, E(): 2.9e-05, (35.7% identity in 129 aa overlap). Contains Pfam match to entry PF00293 mutT, Bacterial mutT protein. (181 aa)    
Predicted Functional Partners:
SCO1685
SCI30A.06, possible integral membrane protein, len: 297aa; similar to many egs. TR:O33234 (EMBL:Z98209) hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores; opt: 356, z-score: 407.0, E(): 2.4e-15, (31.5% identity in 289 aa overlap) and TR:O86668 (EMBL:AL031182) putative integral membrane protein from Streptomyces coelicolor (299 aa) fasta scores; opt: 272, z-score: 312.9, E(): 4.2e-10, (31.5% identity in 279 aa overlap).
       0.744
SCO1683
SCI30A.04c, possible amino acid permease, len: 512 aa; similar to many e.g. TR:Q53148 (EMBL:L24492) ethanolamine permease from Rhodococcus sp. strain NI86/21 (488 aa) fasta scores; opt: 266, z-score: 293.8, E(): 4.9e-09, (26.7% identity in 397 aa overlap). Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains possible membrane spanning hydrophobic regions.
     
 0.702
SCP1.212
Putative bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase; Catalyzes the reaction from prephytoene diphosphate to phytoene; In the N-terminal section; belongs to the phytoene/squalene synthase family.
  
  
 0.573
SCO1687
SCI30A.08, putative membrane protein, len: 130 aa; similar to SW:YIDH_ECOLI hypothetical protein from Escherichia coli (115 aa) fasta scores; opt: 291, z-score: 382.3, E(): 5.8e-14, (47.3% identity in 112 aa overlap). Contains possible hydrophobic membrane spanning regions.
       0.560
SCO1688
SCI30A.09, putative membrane protein, len: 113 aa; similar to SW:YU38_MYCTU hypothetical protein from Mycobacterium tuberculosis (122 aa) fasta scores; opt: 105, z-score: 141.8, E(): 1.4, (34.2% identity in 120 aa overlap). Contains possible hydrophobic membrane spanning regions.
       0.560
SCO1689
SCI30A.10, possible phosphotransferase, len: 341 aa; similar to TR:O69727 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (351 aa) fasta scores; opt: 872, z-score: 1004.6, E(): 0, (43.1% identity in 350 aa overlap). Also weakly similar to TR:Q53826 (EMBL:U13078) capreomycin phopshotransferase from Streptomyces capreolus (281 aa) fasta scores; opt: 142, z-score: 169.4, E(): 0.042, (29.1% identity in 172 aa overlap).
       0.560
SCO1690
SCI30A.11, possible acyl-CoA dehydrogenase, len: 404 aa; varying similarity to many e.g. TR:P96831 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1464, z-score: 1688.2, E(): 0, (57.3% identity in 400 aa overlap) and SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 465, z-score: 539.6, E(): 1e-22, (32.0% identity in 347 aa overlap). Contains two Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase.
       0.560
SCO5091
Cyclase; SCBAC28G1.17, actIV, cyclase, len: 297 aa; identical to previously sequenced TR:Q02057 (EMBL:X63449) Streptomyces coelicolor dehydrogenase ActI ORF5, 297 aa. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.
       0.560
SCO7304
Conserved hypothetical protein SC5F8.14; SC5F8.14, unknown, len: 557 aa. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis TR:P71838(EMBL:Z80226) (566 aa), fasta scores opt: 2386 z-score: 2598.2 E():0 63.1% identity in 553 aa overlap and Deinococcus radiodurans TR:Q9RYS0(EMBL:AE001863) (554 aa), fasta scores opt: 2249 z-score: 2449.3 E():0 60.2% identity in 555 aa overlap.
       0.560
SCO7347
Hypothetical protein; SC9H11.01, unknown, partial CDS, len: >201 aa; SC410.26, unknown, partial CDS, len: >55 aa. Overlaps and extends into CDS SC9H11.01 on the adjoining cosmid.
       0.560
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.