STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1725Putative secreted hydrolase; Catalyzes the hydrolysis of fatty acid esters with a preference for mid-length acyl chain (C10-C16). Is able to hydrolyze the triacylglycerol triolein and mixed triacylglycerols from a wide range of natural oils; better activity is obtained with corn-, wheat germ- and olive oil that have higher content of linoleic and/or oleic acid (C18:2; C18:1, cis). Tween detergents are also substrates for this enzyme. Displays arylesterase activity towards p-nitrophenyl alkanoate esters and alpha- and beta-naphthyl esters. Belongs to the 'GDSL' lipolytic enzyme family. (268 aa)    
Predicted Functional Partners:
SCO1061
SCG22.07, probable bifunctional protein (secreted sugar binding protein/sugar hydrolase), len: 555 aa; N-terminal domain similar to N-terminal domain of TR:O86727 (EMBL:AL031515) Streptomyces coelicolor putative secreted cellulase SC5C7.30c, 890 aa; blastp scores: Score = 84 (29.6 bits), Expect = 0.031, Sum P(3) = 0.030 Identities = 61/233 (26%), Positives = 89/233 (38%) and C-terminal domain similar to C-terminal domain of SW:E13B_OERXA (EMBL:AF052745) Oerskovia xanthineolytica glucan enco-1,3-glucosidase precursor (EC 3.2.1.39), 548 aa; fasta scores: opt: 368 Z-score: 394.8 E(): 2.3e [...]
     
 0.860
SCO1726
SCI11.15, possible ATPase, len: 364 aa; unknown function, very weak similarity to eukaryotic putative ATPases e.g. TR:P78787 (EMBL:D89136) Schizosaccharomyces pombe putative ATPase (partial CDS) (419 aa), fasta scores; opt: 184 z-score: 216.6 E(): 9.9e-05, 26.5% identity in 309 aa overlap and to part of SW:AFG2_YEAST (EMBL:L14615), Agf2, Saccharomyces cerevisiae putative ATPase essential for viability (780 aa) (29.9% identity in 137 aa overlap). Contains weak Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA) and PS00017 ATP/GTP-binding site moti [...]
       0.771
SCO5466
SC3D11.23c, possible hydrolase, len: 185aa; similar to many eg. SW:P34020 (LYC_CLOAB) autolytic lysozyme from Clostridium acetobutylicum (324 aa) fasta scores; opt: 231, z-score: 295.8, E(): 4.6e-09, 29.3% identity in 188 aa overlap.
     
 0.672
SCO3487
SCE65.23, possible hydrolase, len: 798 aa; similar to SW:AGAB_VIBS7 (EMBL:D21202) Vibrio sp. (strain JT0107) beta-agarase B (EC 3.2.1.81) AgaB, 955 aa; fasta socres: opt: 1394 z-score: 1581.4 E(): 0; 39.0% identity in 772 aa overlap. Contains possible hydrophobic membrane spanning region and Leucine TTA codon, possible target for bldA regulation.
      
 0.667
SCO1721
SCI11.10c, hypothetical protein, len: 89 aa; unknown function, possible CDS suggested by GC frameplot.
       0.560
SCO5142
SCP8.05, possible secreted protein, len: 119 aa. Contains possible coiled-coil region at approx residues 77..95 and N-terminal region signal peptide sequence.
  
     0.530
SCO2426
SCC42.07, possible regulatory protein, len: 403 aa; similar to TR:CAB88166 (EMBL:AL352956) Streptomyces coelicolor putative regulatory protein SC1H10.22c, 555 aa; fasta scores: opt: 157 z-score: 183.8 E(): 0.0091; 26.8% identity in 447 aa overlap. Contains a possible helix-turn-helix motif at residues 347..863 (+3.80 SD) and two TTA leucine codons (codon 170 and codon 174), possible targets for bldA regulation.
  
     0.487
SCO5396
2SC6G5.40c, probable cellulose-binding protein, len: 310aa; strongly similar to TR: (EMBL:) AbpS avicel-binding protein from Streptomyces reticuli (311 aa) fasta scores; opt: 1777, z-score: 1598.0, E(): 0, 93.2% identity in 311 aa overlap. Contains a possible membrane-spanning hydrophobic region close to the N-terminus and possible coiled-coil regions throughout.
      
 0.483
SCO1727
SCI11.16, conserved hypothetical protein, len: 255 aa; unknown function, similar hypothetical proteins e.g. TR:O67070 (EMBL:AE000714) Aquifex aeolicus hypothetical protein (252 aa), fasta scores; opt: 459 z-score: 574.9 E(): 1.1e-24, 33.0% identity in 230 aa overlap and the N-terminal half of SW:YECE_ECOLI (EMBL:AE000280) Escherichia coli hypothetical protein (272 aa) (29.0% identity in 155 aa overlap). Similar to TR:Q9ZBF5 (EMBL:AL035206) S. coelicolor hypothetical protein (292 aa) (32.2% identity in 283 aa overlap).
       0.454
SCO1265
2SCG18.12c, probable lipase, len: 289 aa; similar to TR:Q59644 (EMBL:X99255) Propionibacterium acnes triacylglycerol lipase precursor (EC 3.1.1.3) GehA, 339 aa; fasta scores: opt: 423 z-score: 498.8 E(): 2.7e-20; 36.9% identity in 233 aa overlap and to TR:Q9S295 (EMBL:AL096849) Streptomyces coelicolor putative secreted lipase SCI11.24c, 290 aa; fasta scores: opt: 682 z-score: 722.5 E(): 1.2e-34; 47.0% identity in 264 aa overlap. Contains Pfam match to entry PF01674 Lipase_2, Lipase.
  
   
 0.435
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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