STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO1808Putative phosphoserine phosphatase; Catalyzes the dephosphorylation of phosphoserine (P-Ser) in vitro. Also catalyzes the dephosphorylation of phosphothreonine (P-Thr) in vitro. (410 aa)    
Predicted Functional Partners:
SCO4366
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.990
SCO4837
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.968
SCO5364
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.968
SCO5470
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.968
SCO5469
SC2A11.03c, sdaA, probable L-serine dehydratase, len: 455 aa; highly similar to e.g. SDHL_ECOLI L-serine dehydratase 1 (EC 4.2.1.13) (454 aa), fasta scores; opt: 1643 z-score: 1576.6 E(): 0, 55.6% identity in 459 aa overlap.
  
 
 0.953
SCO3077
SCE25.18, probable cystathionine beta-synthase, len: 461 aa; highly similar to TR:O53425 (EMBL:AL021897) Mycobacterium tuberculosis cystathionine beta-synthase CysM, 464 aa; fasta scores: opt: 2025 z-score: 2184.8 E(): 0; 67.6% identity in 454 aa overlap, to TR:Q9YHU3 (EMBL:AF090120) Fugu rubripe cystathionine beta-synthase, 585 aa; fasta scores: opt: 1087 z-score: 1173.5 E(): 0; 39.6% identity in 465 aa overlap and to TR:CAB50991 (EMBL:AL096852) Streptomyces coelicolor putative cysteine synthase SCE19A.10c, 316 aa; fasta scores: opt: 558 z-score: 540.6 E(): 1.4e-24; 40.3% identity in [...]
    
 0.943
SCO2037
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.927
SCO6467
Putative phosphatidylserine synthase; SC9C7.03c, probable integral membrane protein, possible phosphatidylserine synthase, len: 260 aa; similar to many from prokaryotes (all putative) and eukaryotes eg. SW:PSS_YEAST phosphatidylserine synthase from Saccharomyces cerevisiae (275 aa) fasta scores; opt: 187, z-score: 254.6, E(): 6.8e-07, (35.9% identity in 170 aa overlap). Contains possible membrane spanning regions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
  
  0.918
SCO4962
2SCK31.22, probable amino acid deaminase, len: 416 aa; similar to SW:THD2_ECOLI (EMBL:M21312) Escherichia coli threonine deaminase TdcB, 409 aa; fasta scores: opt: 899 z-score: 948.9 E(): 0; 46.0% identity in 309 aa overlap. Contains Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme and match to Prosite entry PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
    
 0.913
SCO7292
SC5F8.02c, possible threonine dehydratase, len: 319 aa. Similar to many including: Escherichia coli SW:THD2_ECOLI(EMBL:M21312) threonine dehydratase catabolic (EC 4.2.1.16) TdcB (329 aa), fasta scores opt: 609 z-score: 676.6 E(): 3.2e-30 39.4% identity in 312 aa overlap. Contains a Prosite hit to Serine/threonine dehydratases pyridoxal-phosphate attachment site and a Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
    
 0.913
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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