STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1895SCI7.13c, probable dihydropicolinate synthase, len: 316 aa; similar to many egs. SW:KDGD_PSEPU 5-dehydro-4-deoxyglutarate dehydratase from Pseudomonas putida (303 aa) fasta scores; opt: 731, z-score: 838.6, E(): 0, (41.1% identity in 302 aa overlap) and SW:DAPA_BACSU dihydropicolinate synthase from Bacillus subtilis (290 aa) fasta scores; opt: 374, z-score: 432.9, E(): 8.8e-17, (29.2% identity in 288 aa overlap). Contains Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family. (316 aa)    
Predicted Functional Partners:
SCO2542
Putative glucarate dehydratase; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc).; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.
 
  
 0.963
SCO7570
SC5F1.24, probable isomerase, len: 375 aa; similar to SW:GUDH_STRCO (EMBL:AL136503) Streptomyces coelicolor probable glucarate dehydratase (EC 4.2.1.40) GudD or SCC77.09c, 431 aa; fasta scores: opt: 553 z-score: 623.1 E(): 3.6e-27; 37.2% identity in 398 aa overlap and to SW:TFDD_ALCEU (EMBL:M35097) Alcaligenes eutrophu chloromuconate cycloisomerase (EC 5.5.1.7) TfdD, 370 aa; fasta scores: opt: 419 z-score: 474.3 E(): 7e-19; 29.1% identity in 385 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. Contains possible hydrophobi [...]
 
  
 0.917
SCO2543
SCC77.10c, possible dihydrodipicolinate synthase. len: 322 aa. Similar to many dihydrodipicolinate synthases including: Bacillus subtilis SW:DAPA_BACSU (EMBL:L08471) dihydrodipicolinate synthase (EC 4.2.1.52) (290 aa), fasta scores opt: 341 z-score: 396.9 E(): 1e-14 26.8% identity in 284 aa overlap and Streptomyces coelicolor TR:Q9X9X7 (EMBL:AL096743) putative dihydropicolinate synthase SCI7.13C (316 aa), fasta scores opt: 927 z-score: 1065.7 E():0 53.1% identity in 294 aa overlap. Contains a Pfam match to entry PF00701 DHDPS; Belongs to the DapA family.
  
  
 
0.906
SCO1894
SCI7.12c, alanine-rich protein, len: 390aa.
 
    0.872
SCO5739
Putative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
  
 0.754
SCO1896
Conserved hypothetical protein; SCI7.14, unknown, len: 269aa; similar to many eg. SW:YTBQ_BACSU hypothetical protein from Bacillus subtilis (253 aa) fasta scores; opt: 262, z-score: 310.1, E(): 6.1e-10, (27.8% identity in 241 aa overlap).
 
   
 0.750
SCO3615
SC66T3.26c, ask, probable aspartokinase, len: 425 aa; highly similar to many e.g. SW:AKAB_MYCSM (EMBL:Z17372), ask, Mycobacterium smegmatis aspartokinase (421 aa), fasta scores; opt: 1839 z-score: 1990.8 E(): 0, 67.4% identity in 427 aa overlap. Homologous genes encode both the alpha and beta subunits of ask by using alternative initiation codons. Codon 253 represents the equivalent position in this sequence, by similarity. Contains Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases and PS00324 Aspartokinase signature.
 
  
 0.681
SCO5353
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
  
 0.627
SCO5793
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
 
  
 0.580
SCO5498
Probable Glu-tRNAGln amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatC family.
  
  
 0.574
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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