node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1214 | SCO1942 | gene:17758797 | gene:17759539 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | 0.978 |
SCO1214 | SCO1945 | gene:17758797 | gene:17759542 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). | 0.815 |
SCO1214 | SCO1947 | gene:17758797 | gene:17759544 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | 0.675 |
SCO1214 | SCO2119 | gene:17758797 | gene:17759717 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. | 0.902 |
SCO1214 | SCO5426 | gene:17758797 | gene:17763078 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.902 |
SCO1214 | SCO6662 | gene:17758797 | gene:17764320 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.923 |
SCO1214 | SCO6663 | gene:17758797 | gene:17764321 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family. | 0.917 |
SCO1214 | SCO7443 | gene:17758797 | gene:17765103 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Phosphoglucomutase; SC6D11.39, pgm, phosphoglucomutase (EC 5.4.2.2), len: 546 aa. Highly similar to many phosphoglucomutases e.g. Escherichia coli SW:PGMU_ECOLI(EMBL:U08369) phosphoglucomutase (EC 5.4.2.2) (546 aa), fasta scores opt: 2216 z-score: 2396.0 E():0 60.8% identity in 538 aa overlap. Contains a Prosite hit to PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature and a Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. | 0.477 |
SCO1937 | SCO1942 | gene:17759534 | gene:17759539 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | 0.982 |
SCO1937 | SCO1945 | gene:17759534 | gene:17759542 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). | 0.846 |
SCO1937 | SCO1947 | gene:17759534 | gene:17759544 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | 0.909 |
SCO1937 | SCO2119 | gene:17759534 | gene:17759717 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. | 0.629 |
SCO1937 | SCO6661 | gene:17759534 | gene:17764319 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.900 |
SCO1937 | SCO6662 | gene:17759534 | gene:17764320 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.902 |
SCO1937 | SCO6663 | gene:17759534 | gene:17764321 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family. | 0.691 |
SCO1937 | SCO7443 | gene:17759534 | gene:17765103 | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | Phosphoglucomutase; SC6D11.39, pgm, phosphoglucomutase (EC 5.4.2.2), len: 546 aa. Highly similar to many phosphoglucomutases e.g. Escherichia coli SW:PGMU_ECOLI(EMBL:U08369) phosphoglucomutase (EC 5.4.2.2) (546 aa), fasta scores opt: 2216 z-score: 2396.0 E():0 60.8% identity in 538 aa overlap. Contains a Prosite hit to PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature and a Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. | 0.939 |
SCO1942 | SCO1214 | gene:17759539 | gene:17758797 | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.978 |
SCO1942 | SCO1937 | gene:17759539 | gene:17759534 | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.982 |
SCO1942 | SCO1945 | gene:17759539 | gene:17759542 | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). | 0.983 |
SCO1942 | SCO1947 | gene:17759539 | gene:17759544 | SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] | Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | 0.974 |