STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1946SCC54.06c, pgk, phosphoglycerate kinase, len: 403 aa; member of a family of proteins highly conserved across prokaryotes and eukaryotes, e.g. SW:PGK_BACSU Pgk, phosphoglycerate kinase from Bacillus subtilis (394 aa) fasta scores; opt: 1263, z-score: 1322.3, E(): 0, (51.2% identity in 404 aa overlap) and SW:PGKH_SPIOL phosphoglycerate kinase from Spinacia oleracea (Spinach) (433 aa) fasta scores; opt: 1200, z-score: 1256.1, E(): 0, (49.9% identity in 407 aa overlap). Contains PS00111 Phosphoglycerate kinase signature and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases, score 6 [...] (403 aa)    
Predicted Functional Partners:
SCO1945
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
 
 0.999
SCO1947
Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]
 0.999
SCO7511
SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...]
 
 0.999
SCO7040
SC4G1.06c, gap2, glyceraldehyde-3-phosphate dehydrogenase, len: 481 aa; highly similar to TR:O68923 (EMBL:AF058302) Streptomyces roseofulvus glyceraldehyde-3-phosphate dehydrogenase homolog GapX, 461 aa; fasta scores: opt: 2562 z-score: 2921.8 E(): 0; 84.5% identity in 459 aa overlap and to many eukaryotic homologos, e.g. SW:G3PA_MAIZE (EMBL:X15408) Zea mays glyceraldehyde-3-phosphate dehydrogenase A, chloroplast precursor (EC 1.2.1.12) GapA, 403 aa; fasta scores: opt: 793 z-score: 907.5 E(): 0; 39.6% identity in 366 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde [...]
 
 0.997
SCO3096
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 
 0.996
SCO7638
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 
 0.996
SCO4209
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
 0.995
SCO6818
Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
 
 0.988
SCO0578
SCF55.02c, possible triosephosphate isomerase, len: 259 aa; similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA, 261 aa; fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20; 38.9% identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM, Triosephosphate isomerase.
 
 0.985
SCO2014
SC7H2.28c, pyk1, pyruvate kinase, len: 478 aa; strongly similar to many e.g. SW:KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores; opt: 1800, z-score: 2008.1, E(): 0, (59.6% identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature.
 
 
 0.972
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.