node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1438 | SCO2044 | gene:17759024 | gene:17759642 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.994 |
SCO1438 | SCO2048 | gene:17759024 | gene:17759646 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.992 |
SCO1438 | SCO2050 | gene:17759024 | gene:17759648 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan; Belongs to the HisA/HisF family. | 0.990 |
SCO1438 | SCO2051 | gene:17759024 | gene:17759649 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | hisH, amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.987 |
SCO1438 | SCO2052 | gene:17759024 | gene:17759650 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | SC4G6.21c, hisB, imidazoleglycerol-phosphate dehydratase, len: 197aa; previously sequenced therefore identical to SW:HIS7_STRCO. Contains Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase and Prosite matches to PS00955 Imidazoleglycerol-phosphate dehydratase signature 2 and PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. | 0.994 |
SCO1438 | SCO2053 | gene:17759024 | gene:17759651 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. | 0.975 |
SCO1438 | SCO2054 | gene:17759024 | gene:17759652 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |
SCO1761 | SCO2053 | gene:17759355 | gene:17759651 | SCI51.01c, possible cyclohexadienyl dehydrogenase, partial CDS, len: >212 aa; similar to several cyclohexadienyl dehydrogenases e.g. SW:TYRC_ZYMMO (EMBL:M75891), TyrC, Zymomonas mobilis cyclohexadienyl dehydrogenase (293 aa), fasta scores; opt: 299 z-score: 344.0 E(): 7.8e-12, 31.4% identity in 220 aa overlap. Also similar to other hypothetical oxidoreductases e.g. CZA382.29 (EMBL:AL078635) Streptomyces coelicolor putative oxidoreductase (367 aa) (55.8% identity in 208 aa overlap); 2SCI34.14c, possible oxidoreductase (fragment) (putative secreted protein), len: >182 aa; similar to TR:Q [...] | SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. | 0.964 |
SCO1761 | SCO3221 | gene:17759355 | gene:17760839 | SCI51.01c, possible cyclohexadienyl dehydrogenase, partial CDS, len: >212 aa; similar to several cyclohexadienyl dehydrogenases e.g. SW:TYRC_ZYMMO (EMBL:M75891), TyrC, Zymomonas mobilis cyclohexadienyl dehydrogenase (293 aa), fasta scores; opt: 299 z-score: 344.0 E(): 7.8e-12, 31.4% identity in 220 aa overlap. Also similar to other hypothetical oxidoreductases e.g. CZA382.29 (EMBL:AL078635) Streptomyces coelicolor putative oxidoreductase (367 aa) (55.8% identity in 208 aa overlap); 2SCI34.14c, possible oxidoreductase (fragment) (putative secreted protein), len: >182 aa; similar to TR:Q [...] | SCE8.14c, probable oxidoreductase, len: 284 aa; similar to many e.g. TR:O52817 (EMBL:AJ223999) protein similar to prephenate dehydrogenase from the vancomycin biosynthesis of Amycolatopsis orientalis (367 aa) fasta scores; opt: 757, z-score: 865.8, E(): 0, (49.8% identity in 283 aa overlap) and SW:TYRA_BACSU prephenate dehydrogenase from Bacillus subtilis (372 aa) fasta scores; opt: 251, z-score: 291.1, E(): 6.6e-09, (28.3% identity in 251 aa overlap). | 0.907 |
SCO1761 | SCO3962 | gene:17759355 | gene:17761589 | SCI51.01c, possible cyclohexadienyl dehydrogenase, partial CDS, len: >212 aa; similar to several cyclohexadienyl dehydrogenases e.g. SW:TYRC_ZYMMO (EMBL:M75891), TyrC, Zymomonas mobilis cyclohexadienyl dehydrogenase (293 aa), fasta scores; opt: 299 z-score: 344.0 E(): 7.8e-12, 31.4% identity in 220 aa overlap. Also similar to other hypothetical oxidoreductases e.g. CZA382.29 (EMBL:AL078635) Streptomyces coelicolor putative oxidoreductase (367 aa) (55.8% identity in 208 aa overlap); 2SCI34.14c, possible oxidoreductase (fragment) (putative secreted protein), len: >182 aa; similar to TR:Q [...] | SCD78.29c, pheA, prephenate dehydratase, len: 310 aa, similar to many eg. PHEA_AMYME (EMBL:L47666) prephenate dehydratase from Amycolatopsis methanolica (304 aa), fasta scores; opt: 821, z-score: 1164.7, E(): 0, 46.9% identity in 305 aa overlap. Contains PS00857 Prephenate dehydratase signature 1 and Pfam match to entry PF00800 PDT, Prephenate dehydratase, score 354.80, E-value 9.5e-103. Note: Can participate in the biosynthesis of Phenylalanine, Tyrosine and Tryptophan. | 0.974 |
SCO2044 | SCO1438 | gene:17759642 | gene:17759024 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |
SCO2044 | SCO2048 | gene:17759642 | gene:17759646 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.991 |
SCO2044 | SCO2050 | gene:17759642 | gene:17759648 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan; Belongs to the HisA/HisF family. | 0.999 |
SCO2044 | SCO2051 | gene:17759642 | gene:17759649 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | hisH, amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.987 |
SCO2044 | SCO2052 | gene:17759642 | gene:17759650 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | SC4G6.21c, hisB, imidazoleglycerol-phosphate dehydratase, len: 197aa; previously sequenced therefore identical to SW:HIS7_STRCO. Contains Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase and Prosite matches to PS00955 Imidazoleglycerol-phosphate dehydratase signature 2 and PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. | 0.994 |
SCO2044 | SCO2053 | gene:17759642 | gene:17759651 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. | 0.955 |
SCO2044 | SCO2054 | gene:17759642 | gene:17759652 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
SCO2048 | SCO1438 | gene:17759646 | gene:17759024 | Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.992 |
SCO2048 | SCO2044 | gene:17759646 | gene:17759642 | Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.991 |
SCO2048 | SCO2050 | gene:17759646 | gene:17759648 | Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan; Belongs to the HisA/HisF family. | 0.999 |