STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO2053SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. (369 aa)    
Predicted Functional Partners:
SCO2051
hisH, amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
  
 0.999
SCO2052
SC4G6.21c, hisB, imidazoleglycerol-phosphate dehydratase, len: 197aa; previously sequenced therefore identical to SW:HIS7_STRCO. Contains Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase and Prosite matches to PS00955 Imidazoleglycerol-phosphate dehydratase signature 2 and PS00954 Imidazoleglycerol-phosphate dehydratase signature 1.
 
 0.999
SCO2054
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
SCO2050
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan; Belongs to the HisA/HisF family.
 
  
 0.995
SCO2048
Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
  
 0.988
SCO1438
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.975
SCO1761
SCI51.01c, possible cyclohexadienyl dehydrogenase, partial CDS, len: >212 aa; similar to several cyclohexadienyl dehydrogenases e.g. SW:TYRC_ZYMMO (EMBL:M75891), TyrC, Zymomonas mobilis cyclohexadienyl dehydrogenase (293 aa), fasta scores; opt: 299 z-score: 344.0 E(): 7.8e-12, 31.4% identity in 220 aa overlap. Also similar to other hypothetical oxidoreductases e.g. CZA382.29 (EMBL:AL078635) Streptomyces coelicolor putative oxidoreductase (367 aa) (55.8% identity in 208 aa overlap); 2SCI34.14c, possible oxidoreductase (fragment) (putative secreted protein), len: >182 aa; similar to TR:Q [...]
  
 
 0.964
SCO3221
SCE8.14c, probable oxidoreductase, len: 284 aa; similar to many e.g. TR:O52817 (EMBL:AJ223999) protein similar to prephenate dehydrogenase from the vancomycin biosynthesis of Amycolatopsis orientalis (367 aa) fasta scores; opt: 757, z-score: 865.8, E(): 0, (49.8% identity in 283 aa overlap) and SW:TYRA_BACSU prephenate dehydrogenase from Bacillus subtilis (372 aa) fasta scores; opt: 251, z-score: 291.1, E(): 6.6e-09, (28.3% identity in 251 aa overlap).
  
 
 0.964
SCO2044
Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.955
SCO3962
SCD78.29c, pheA, prephenate dehydratase, len: 310 aa, similar to many eg. PHEA_AMYME (EMBL:L47666) prephenate dehydratase from Amycolatopsis methanolica (304 aa), fasta scores; opt: 821, z-score: 1164.7, E(): 0, 46.9% identity in 305 aa overlap. Contains PS00857 Prephenate dehydratase signature 1 and Pfam match to entry PF00800 PDT, Prephenate dehydratase, score 354.80, E-value 9.5e-103. Note: Can participate in the biosynthesis of Phenylalanine, Tyrosine and Tryptophan.
 
 
 0.930
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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