STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
SCO2076Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1047 aa)    
Predicted Functional Partners:
SCO2571
SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V).
  
 0.998
SCO5699
Prolyl tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
   
 0.994
SCO5547
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
  
 0.987
SCO6436
SC9B5.03, probable tRNA synthetase, len: 506 aa; similar to many eg. SW:SYM_METTH methionyl-tRNA synthetase from Methanobacterium thermoautotrophicum (651 aa) fasta scores; opt: 610, z-score: 560.9, E(): 5.9e-24, (28.9% identity in 402 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
 
 0.983
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
  
 
 0.980
SCO3304
SCE68.02, argS, probable arginyl-tRNA synthetase, len: 586 aa; similar to many e.g. SW:SYR_ECOLI (EMBL:X15320), argS, Escherichia coli arginyl-tRNA synthetase (577 aa), fasta scores; opt: 1415 z-score: 1562.9 E(): 0, 43.8% identity in 587 aa overlap. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R) and PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
 
 0.977
SCO5352
SCBAC5H2.21, possible arginyl tRNA synthetase, len: 347 aa; similar to SW:SYR_BRELA (EMBL:Z21501) Brevibacterium lactofermentum arginyl tRNA synthetase (EC 6.1.1.19) ArgS, 550 aa; fasta scores (to C-terminal region): opt: 234 z-score: 260.2 E(): 6.4e-07; 36.0% identity in 161 aa overlap and blastp scores (to N-terminal region): Score = 182 (64.1 bits), Expect = 1.2e-28, Sum P(2) = 1.2e-28; Identities = 45/116 (38%), Positives = 65/116 (56%) and similar to SW:SYR_MYCTU (EMBL:Z73419) Mycobacterium tuberculosis arginyl t-RNA synthetase (EC 6.1.1.19) ArgS or MTCY373.12, 550 aa; fasta score [...]
  
 0.970
SCO3792
Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.951
SCO2615
Valyl tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
 
0.929
SCO3406
Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
  
  
 0.880
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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