STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO2109Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)    
Predicted Functional Partners:
SCO2107
SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...]
 
 0.999
SCO2108
SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap).
 
 
 0.999
SCO2104
Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.992
SCO5563
Phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
 
  
 0.967
SCO3928
Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.958
SCO5178
2SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain.
 
  
 0.957
SCO6013
Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.949
SCO6768
Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.949
SCO4294
SCD95A.27, hypothetical protein, len: 91 aa; similar to SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical 9.6 kD protein MTCY130.20, 93 aa; fasta scores: opt: 369 z-score: 480.3 E(): 2.7e-19; 63.4% identity in 93 aa overlap, to TR:CAB50992 (EMBL:AL096852) Streptomyces coelicolor hypothetical protein SCE19A.11c, 92 aa; fasta scores: opt: 332 z-score: 416.4 E(): 1.2e-17; 54.9% identity in 91 aa overlap and highly similar to TR:Q9EUR9 (EMBL:AJ250537) Streptomyces hygroscopicus hypothetical protein, 92 aa; fasta scores: opt: 496 Z-score: 626.4 E(): 2.9e-27; 83.516% identi [...]
 
 
 
 0.928
SCO2911
SCE19A.11c, conserved hypothetical protein, len: 92 aa; unknown function, similar to hypothetical proteins from other organisms e.g. SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (93 aa), fasta scores; opt: 341 z-score: 451.3 E(): 8.3e-18, 57.0% identity in 93 aa overlap.
   
 
 0.918
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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