STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2110SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...] (667 aa)    
Predicted Functional Partners:
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.986
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 0.985
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.977
SCO3843
Hypothetical protein; SCH69.13, unknown, len: 290 aa; similar to the N-terminal region of TR:P71590 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (527 aa) fasta scores; opt: 268, z-score: 221.4, E(): 5.3e-05, (28.1% identity in 217 aa overlap).
 
 
 
 0.957
SCO3844
SCH69.14, putative secreted protein, len: 172 aa; similar to TR:P71589 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (155 aa) fasta scores; opt: 389, z-score: 442.8, E(): 2.5e-17, (46.2% identity in 171 aa overlap). Contains possible N-terminal region signal peptide sequence.
 
 
 
 0.957
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.949
SCO1806
Putative ABC transporter ATP-binding protein; SCI33.05c, conserved hypothetical protein, len: 876 aa; similar to TR:O65934 (EMBL:Z95890) Mycobacterium tuberculosis hypothetical 92.2 kDa protein MTCY28.10, 865 aa; fasta scores: opt: 1196 z-score: 907.2 E(): 0; 37.8% identity in 883 aa overlap and to TR:AAK46062 (EMBL:AE007039) Mycobacterium tuberculosis ABC transporter, ATP-binding protein MT1789, 863 aa; fasta scores: opt: 1196 Z-score: 892.8 E(): 4.3e-42; 37.826% identity in 883 aa overlap. Contains 2x Pfam matches to entry PF00498 FHA, FHA domain (N-terminal region) and Pfam match to [...]
  
 
 0.942
SCO6079
SCBAC1A6.03, conserved hypothetical protein, len: 183 aa; similar to TR:Q9RP36 (EMBL:AF173844) Mycobacterium smegmatis putative signal transduction protein GarA, 158 aa; fasta scores: opt: 185 z-score: 231.8 E(): 2.5e-05; 36.4% identity in 143 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.925
SCO2975
Hypothetical protein SCE50.03; SCE50.03, unknown, len: 1345 aa. High G+C content (80.71%) and high also in alanine, glycine and proline amino acid residues.
  
 
 0.923
SCO2669
Hypothetical protein SC6D10.12; SC6D10.12, unknown, len: 604 aa. Glycine and proline rich. Contains Pfam match to entry PF00498 FHA, FHA domain.
   
 
 0.902
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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