STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2450SCC24.21, possible serine/threonine protein kinase (regulator), len: 1349 aa; N-terminal region similar to SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa; blastp socres: Score = 109 (38.4 bits), Expect = 0.00070, Sum P(2) = 0.00070 Identities = 39/121 (32%), Positives = 60/121 (49%) and C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR, 993 aa; fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17; 33.3% identity in 442 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryoti [...] (1349 aa)    
Predicted Functional Partners:
SCO2449
SCC24.20, conserved hypothetical protein, len: 340 aa; similar to TR:Q9F3J5 (EMBL:AL391763) Streptomyces coelicolor conserved hypothetical protein 340 aa; fasta scores: opt: 1113 Z-score: 1094.9 E(): 2.4e-53; 54.519% identity in 343 aa overlap.
 
    0.834
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.816
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 
 0.808
SCO7291
SC5H1.01, probable serine/threonine protein kinase, partial CDS, len: >459 aa; similar to many eukaryotic-type e.g. SW:AFSK_STRCO (EMBL:D15062), afsK, Streptomyces coelicolor eukaryotic-type protein kinase involved in secondary metabolism (799 aa), fasta scores; opt: 261 z-score: 221.3 E(): 5.3e-05, 30.3% identity in 498 aa overlap and SW:KRCB_RAT (EMBL:D30041) Rattus norvegicus RAC-beta serine/threonine kinase (481 aa) (31.4% identity in 169 aa overlap). A hydrophobic region is present, so it is possible that the protein spans a membrane. Contains Pfam match to entry PF00069 pkinase, [...]
  
 
   0.787
SCO2244
SC1G2.06c, probable serine/threonine protein kinase, len: 686 aa. Highly similar to many serine/threonine protein kinases including: Streptomyces coelicolor SW:AFSK_STRCO (EMBL:D15062) AfsK (799 aa), fasta scores opt: 818 z-score: 736.0 E():0 34.2% identity in 658 aa overlap and Thermomonospora curvata SW:PKWA_THECU (EMBL:U23820) PkwA (742 aa), fasta scores opt: 1065 z-score: 956.9 E():0 37.0% identity in 763 aa overlap. Contains a Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and 3xPfam matches to entry PF00400 WD40, WD domain, G-beta repeat. Also contains Pros [...]
 
   0.786
SCO4778
SCD63.10, pkaI, serine/threonine protein kinase, len: 380 aa; similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor putative protein serine/threonine kinase SCI11.13, 550 aa; fasta scores: opt: 932 z-score: 751.0 E(): 0; 45.0% identity in 416 aa overlap and to SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaA (EC 2.7.1.-), 543 aa; fasta scores: opt: 557 z-score: 454.6 E(): 6.8e-18; 33.9% identity in 386 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein [...]
  
 
   0.786
SCO2973
SCE59.32c, pkaB, serine/threonine protein kinase (partial), len: >233 aa; identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains possible hydrophobic membrane spanning region; SCE50.01, pkaB, serine/threonine protein kinase (fragment), len: >222 aa; identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB (EC 2.7.1.- [...]
  
 
   0.785
SCO4777
SCD63.09, pkaD, protein serine/threonine kinase, len: 599 aa; identical to previously sequenced TR:O83032 (EMBL:AB016932) Streptomyces coelicolor protein serine/threonine kinase PkaD. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Serine/Threonine protein kinases active-site signature and possible hydrophobic membrane spanning region.
  
 
   0.785
SCO4779
SCD63.11, pkaJ, serine/threonine protein kinase, len: 548 aa; N-terminal region similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor putative protein serine/threonine kinase SCI11.13, 550 aa; fasta scores: opt: 1006 z-score: 815.3 E(): 0; 56.9% identity in 297 aa overlap and to TR:AAD47061 (EMBL:AF159501) Myxococcus xanthus Pkn4, 643 aa; fasta scores: opt: 639 z-score: 521.3 E(): 1.4e-21; 43.6% identity in 273 aa overlap and C-terminal similar to TR:Q9WTP4 (EMBL:AB019577) Mus musculus UNC-51-like kinase (ULK) 2, Ulk2, 1037 aa; blastp socres: Sum P(2) = 2.6e-24 Identities = 89 [...]
  
 
   0.785
SCO6861
SC7F9.13c, pk3, protein kinase-like protein, 565 aa. Previously sequenced therefore identical to Streptomyces coelicolor TR:Q53839(EMBL:U19250). Contains Prosite hits to PS00107 Protein kinases ATP-binding region signature and PS00108 Serine/Threonine protein kinases active-site signature. Also contains a Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain.
  
 
   0.785
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.