STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2560Conserved hypothetical protein; SCC77.27c, unknown, len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1% identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa), fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1% identity in 178 aa overlap. (792 aa)    
Predicted Functional Partners:
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
 
 0.917
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.895
SCO2559
Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
       0.875
SCO2558
Hypothetical protein SCC77.25c; SCC77.25c, unknown, len: 224 aa.
       0.856
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.853
SCO2817
SCBAC17F8.08c, conserved hypothetical protein, len: 634 aa: similar in regions to many proteins of varying lengths e.g. TR:Q9RCY2 (EMBL:AL133469) hypothetical protein SCM10.16c from Streptomyces coelicolor (714 aa) fasta scores; opt: 1259, Z-score: 1358.4, 43.960% identity (46.454% ungapped) in 596 aa overlap and TR:Q9HVI8 (EMBL:AE004874) hypothetical protein from Pseudomonas aeruginosa (1415 aa) fasta scores; opt: 961, Z-score: 1032.5, 36.825% identity (40.250% ungapped) in 611 aa overlap. Contains Pfam match to entry PF00563 EAL, Domain of unknown function and Pfam match to entry PF0 [...]
  
 
 0.839
SCO0717
SCF42.27, possible integral membrane protein, len: 375 aa. Similar to several other membrane proteins from Streptomyces coelicolor e.g. TR:CAB56388(EMBL:AL118515) SCD17.11 (454 aa), fasta scores opt: 569 z-score: 648.9 E(): 9.3e-29 36.4% identity in 360 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
   0.824
SCO6390
SC3C8.09, probable integral membrane protein, len: 367 aa; similar to a hypothetical protein from M. tuberculosis Y07S_MYCTU MTCY02B10.28c (653 aa), fatsta scores; opt: 144 z-score: 314.2 E(): 2.9e-10, 30.6% identity in 281 aa overlap. Also similar to S. coelicolor SC7H1.03c (E(): 3e-18, 35.2% identity in 355 aa overlap).
  
   0.820
SCO7380
Conserved hypothetical protein; SC10G8.07c, unknown, len: 437 aa. Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein, SC9C7.20 (860 aa), fasta scores opt: 271 z-score: 309.7 E(): 7.7e-10 30.3% identity in 274 aa overlap.
  
   0.815
SCO6321
SCIF3.23, possible integral membrane protein, len: 362 aa; highly similar to TR:Q9KZX9 (EMBL:AL353815) Streptomyces coelicolor putative integral membrane protein SCD6.25, 362 aa; fasta scores: opt: 1695 z-score: 1862.4 E(): 0; 73.8% identity in 362 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
   0.814
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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