STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2624SCC80.09c, possible integral membrane protein, len: 395 aa; similar to TR:Q9RL36 (EMBL:AL121596) Streptomyces coelicolor hypothetical 29.6 kDa protein SCF51A.29c, 284 aa; fasta scores: opt: 269 z-score: 309.0 E(): 1.1e-09; 31.0% identity in 258 aa overlap. Contains possible hydrophobic membrane spanning regions. (395 aa)    
Predicted Functional Partners:
SCO2623
SCC80.08c, hypothetical protein, len: 164 aa; similar to N-terminal domain of SW:RELA_CORGL (EMBL:AF038651) Corynebacterium glutamicum GTP pyrophosphokinase (EC 2.7.6.5) RelA, 760 aa; fasta scores: opt: 162 z-score: 170.8 E(): 0.054; 33.6% identity in 149 aa overlap. Contains 3x conserved repeat: MPP.
       0.849
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
 0.824
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
  
   0.801
SCO7009
Conserved hypothetical protein; SC8F11.35c, unknown, len: 593 aa. Identical, apart from the very C-terminus, to Streptomyces lividans TR:O86875(EMBL:U22894) hypothetical 57.9 kd protein, AglX (547 aa), fasta scores opt: 3357 z-score: 3741.0 E(): 0 98.8% identity in 519 aa overlap. Also highly similar to several Streptomyces coelicolor hypothetical proteins e.g. TR:CAB61537(EMBL:AL133171) SCF81.26 (835 aa), fasta scores opt: 1133 z-score: 1260.6 E(): 0 43.0% identity in 575 aa overlap.
 
   0.782
SCO2560
Conserved hypothetical protein; SCC77.27c, unknown, len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1% identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa), fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1% identity in 178 aa overlap.
  
   0.779
SCO3284
SCE15.01, partial CDS, conserved hypothetical protein, len: >436aa; similar to C-terminal region of TR:CAA22732 (EMBL:AL035161) another conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 922, z-score: 1011.5, E(): 0, (39.5% identity in 425 aa overlap); SCE39.34, unknown, len: >307aa; similar to TR:E1370406 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 254, z-score: 277.0, E(): 4e-08, (29.2% identity in 277 aa overlap) TR:O86875 (EMBL:U22894) hypothetical protein from Streptomyces lividans (54 [...]
 
 
 0.769
SCO2625
SCC80.10, hypothetical protein, len: 413 aa; similar to TR:CAB94090 (EMBL:AL358692) Streptomyces coelicolor conserved hypothetical protein SCD66.23, 418 aa; fasta scores: opt: 698 z-score: 807.3 E(): 0; 35.8% identity in 419 aa overlap.
       0.763
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
  
   0.754
SCO5104
SCBAC28G1.30, hypothetical protein, len: 880 aa; similar to many Streptomyces coelicolor hypothetical proteins, e.g. TR:Q9KYN1 (EMBL:AL356592) hypothetical 84.7 kDa protein SC9H11.08, 802 aa; fasta scores: opt: 1062 Z-score: 1155.9 bits: 224.9 E(): 9.1e-57; 38.902% identity in 856 aa overlap. Contains 2x Pfam matches, Pfam match to entry PF01590 GAF, GAF domain, to entry PF00989 PAS, PAS domain and to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase.
 
  
 0.732
SCO4410
SC6F11.08, possible anti anti sigma factor, len: 126 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG, 113 aa; fasta scores: opt: 195 z-score: 264.4 E(): 3.2e-07; 30.8% identity in 104 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
  
   0.704
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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