STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2667Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa. (482 aa)    
Predicted Functional Partners:
SCO2666
SC6D10.09, possible serine/threonine protein kinase, len: 903 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 1045 z-score: 821.3 E(): 0; 42.0% identity in 793 aa overlap and to SW:PKN2_MYXXA (EMBL:M94857) Myxococcus xanthus serine/threonine-protein kinase Pkn2 (EC 2.7.1.-), 830 aa; fasta scores: opt: 301 z-score: 243.3 E(): 3.8e-06; 28.9% identity in 433 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and match to Prosite entry PS00402 Binding-protein-depe [...]
 
 
 0.974
SCO3848
SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...]
 
 
 0.951
SCO2110
SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...]
 
 
 0.949
SCO2668
SC6D10.11, hypothetical protein, len: 452 aa; similar to TR:Y103_SYNY3 (EMBL:D64004) Synechocystis sp. hypothetical 45.8 kD protein SLL0103, 420 aa; fasta scores: opt: 265 z-score: 295.0 E(): 5.1e-09; 26.6% identity in 354 aa overlap.
 
     0.940
SCO2669
Hypothetical protein SC6D10.12; SC6D10.12, unknown, len: 604 aa. Glycine and proline rich. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 0.927
SCO2665
Hypothetical protein SC6D10.08; SC6D10.08, unknown, len: 444 aa. Contains possible coiled-coil region.
 
     0.906
SCO1468
SCL6.25c, possible serine/threonine protein kinase, len: 774 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 682 z-score: 645.1 E(): 1.6e-28; 36.0% identity in 736 aa overlap and to SW:KMOS_MSVMO (EMBL:V01180) Moloney murine sarcoma virus MOS serine/threonine-protein kinase transforming protein (EC 2.7.1.-) V-MOS, 374 aa; fasta scores: opt: 230 z-score: 224.5 E(): 4.4e-05; 23.4% identity in 269 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain.
 
 
 0.902
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
 
 0.837
SCO2663
SC6D10.06, possible secreted protein, len: 429 aa; similar to TR:P96258 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 47.1 kD protein MTCY22G10.08c, 439 aa; fasta scores: opt: 430 z-score: 482.8 E(): 1.8e-19; 30.9% identity in 427 aa overlap and to TR:Q9ZBL6 (EMBL:AL035159) Mycobacterium leprae putative membrane protein MLCB1450.21c, 403 aa; fasta scores: opt: 412 z-score: 463.3 E(): 2.1e-18; 29.6% identity in 423 aa overlap. Contains possible N-terminal region signal peptide sequence.
 
     0.790
SCO1467
SCL6.24c, hypothetical protein, len: 491 aa; similar to TR:CAB71206 (EMBL:AL138538) Streptomyces coelicolor hypothetical 47.0 kD protein SC6D10.11, 452 aa; fasta scores: opt: 835 z-score: 861.3 E(): 0; 37.6% identity in 434 aa overlap.
 
     0.774
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: medium (62%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.