STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2705Putative membrane protein; One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins. Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation. Chaplins are also involved in cell attachment to a hydrophobic surfa [...] (88 aa)    
Predicted Functional Partners:
SCO2707
SCC61A.28, possible transferase (membrane-associated), len: 484 aa; similar to many proposed to be involved in LPS biosynthesis e.g. SW:P71241 (WCAJ_ECOLI) putative colanic biosynthesis UDP-glucose lipid carrier transferase from Escherichia coli (464 aa) fasta scores; opt: 493, z-score: 540.1, E(): 1.3e-22, 30.9% identity in 376 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
    0.767
SCO2706
SCC61A.27, possible transferase, len: 436 aa; similar to many proposed to be involved in LPS biosynthesis e.g. SW:LPSB_RHIME (EMBL:AF193023) LpsB from lipopolysaccharide biosynthesis cluster of Rhizobium meliloti. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Also contains a TTA encoded leucine close to the N-terminus, possible target for bldA regulation.
       0.763
SCO2704
SCC61A.25c, possible secreted protein, len: 244aa; contains a possible cleavable N-terminal signal sequence.
     
 0.732
SCO7637
SC10F4.10c, secreted endoglucanase, len: 486 aa; highly similar to SW:GUNA_STRLI (EMBL:M82807) Streptomyces lividans endoglucanase CelA precursor (EC 3.2.1.4) CelA, 459 aa; fasta scores: opt: 2977 z-score: 3136.1 E(): 0; 97.4% identity in 461 aa overlap. Contains Pfam matches to entries PF00553 CBD_2, Cellulose binding domain and PF00150 cellulase, Cellulase (glycosyl hydrolase family 5) and matches to Prosite entries PS00561 Cellulose-binding domain, bacterial type and PS00659 Glycosyl hydrolases family 5 signature. Also contains possible N-terminal region signal peptide sequence.
    
 
 0.689
SCO2709
SCC61A.30, possible integral membrane protein, len: 523aa; similar to many proposed virulence factors eg. SW:P37169 (MVIN_SALTY) virulence factor MviN from Salmonella typhimurium (524 aa) fasta scores; opt: 475, z-score: 495.1, E(): 4e-20, 28.8% identity in 423 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.615
SCO1801
SCI5.09c, possible two component response regulator, len: 210aa; similar to many eg. TR:CAB42027 (EMBL:AL049754) putative two component response regulator from Streptomyces coelicolor (228 aa) fasta scores; opt: 622, z-score: 715.0, E(): 1.7e-32, (48.6% identity in 214 aa overlap) and SW:NARL_ECOLI nitrite/nitrate response regulator from Escherichia coli (216 aa) fasta scores; opt: 512, z-score: 591.0, E(): 1.4e-25, (39.9% identity in 203 aa overlap). Contains Pfam matches to PF00196 Bacterial regulatory proteins, luxR family and PF00072 Response regulator receiver domain, and Prosite [...]
       0.560
SCO1802
SCI33.01c, possible two-component system sensor kinase (fragment), len: >383 aa; similar to N-terminal region of TR:Q9L1F1 (EMBL:AL157916) Streptomyces coelicolor putative two-component system sensor kinase SC3D11.11, 442 aa; fasta scores: opt: 406 z-score: 434.9 E(): 1.1e-16; 38.9% identity in 211 aa overlap. Contains Pfam matches to entries PF01590 GAF, GAF domain and PF02518 HATPase_c, GAF domain; SCI5.10c, partial CDS, possible two component sensor kinase, len: >41aa; similar to the C-terminus of many egs. TR:Q52558 (EMBL:U02041) VsrA, virulence regulator from Ralstonia solanacearu [...]
       0.560
SCO2708
SCC61A.29, possible integral membrane protein, len: 438aa; weakly similar to TR:Q51524 (EMBL:X83916) PilO, required for glycosylation of Pseudomonas aeruginosa 1244 pilin (461 aa) fasta scores; opt: 165, z-score: 184.2, E(): 0.0085, 25.7% identity in 439 aa overlap.
       0.556
SCO2718
Putative secreted protein; Probably forms part of the rodlet layer on the spore surface; despite their high similarity both RdlA and RdlB are required for rodlet formation. Plays a role in cell adhesion to polystyrene plates. Does not form amyloid fibrils in vitro, unlike RdlB. Belongs to the rodlin family.
     
 0.550
SCO2711
SCC61A.32, possible glycosyl transferase, len: 400 aa; weakly similar to others proposed to be involved in LPS biosynthesis e.g. TR:AAF23993 (EMBL:AF035937) from Pseudomonas aeruginosa (383 aa) fasta scores; opt: 381, z-score: 364.0, E(): 8.2e-13, 28.6% identity in 392 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1.
       0.546
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: medium (42%) [HD]