STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2724SCC46.09c, possible amino acid transporter, len: 476 aa; similar to TR:BAA87325 (EMBL:AB020520) Rattus norvegicus Y+L amino acid transporter 1, RT+Lat1, 512 aa; fasta scores: opt: 354 z-score: 394.6 E(): 1.5e-14; 26.3% identity in 460 aa overlap. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains also possible hydrophobic membrane spanning regions. (476 aa)    
Predicted Functional Partners:
SCO2723
SCC46.08c, probable ABC transporter ATP-binding protein, len: 866 aa; C-terminal region similar to SW:YHCH_BACSU (EMBL:X96983) Bacillus subtilis hypothetical ABC transporter ATP-binding protein 2 in GlpD-CspB intergenic region, YhcH, 305 aa; fasta scores: opt: 597 z-score: 577.6 E(): 9.3e-25; 36.6% identity in 303 aa overlap and to SW:BCRA_BACLI (EMBL:L20573) Bacillus licheniformis bacitracin transport ATP-binding protein BcrA, 306 aa; fasta scores: opt: 581 z-score: 562.3 E(): 6.6e-24; 38.8% identity in 304 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and [...]
  
 
 0.767
SCO2722
SCC46.07c, possible integral membrane protein, len: 299 aa. Contains possible hydrophobic membrane spanning regions.
  
    0.736
SCO1859
SCI39.06, probable aminotransferase, len: 339 aa; similar to SW:HIS8_ECOLI (EMBL:X03416) Escherichia coli histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC, 356 aa; fasta scores: opt: 351 Z-score: 375.7 bits: 78.0 E(): 2.4e-13; 29.450% identity in 309 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferase class-II and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
      
 0.648
SCO3944
Putative histidinol-phophate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
      
 0.648
SCO5257
Methyltransferase; 2SC7G11.19, metZ, methyltransferase, len: 269 aa; previously sequenced as TR:Q9RGW5 (EMBL:AF104994) Streptomyces coelicolor A3(2) methyltransferase MetZ, 268 aa.
      
 0.519
SCO2640
Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
   
 
 0.512
SCO3614
Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
   
 
 0.512
SCO3782
SCH63.29c, possible regulatory protein, len: 449 aa; similar to TR:O86603 (EMBL:AL031155) Streptomyces coelicolor transcriptional regulator SC3A7.02c, 892 aa; blastp scores: Score = 148 (52.1 bits), Expect = 6.7e-07, P = 6.7e-07; Identities = 98/317 (30%), Positives = 130/317 (41%). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and 4x matches to entry PF00515 TPR, TPR Domain.
  
     0.507
SCO2012
SC7H2.26, probable branched chain amino acid transport ATP-binding protein, len: 238aa; similar to many eg. SW:LIVF_ECOLI branched chain amino acid transport ATP-binding protein from Escherichia coli (237 aa) fasta scores; opt: 774, z-score: 860.8, E(): 0, (52.4% identity in 233 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
      
 0.505
SCO2905
Hypothetical protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine (GlcNAc) transport.
      
 0.494
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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