STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2833SCE20.07c, chb, secreted chitin binding protein, len: 201 aa. Highly similar to several including: Streptomyces olivaceoviridis (Streptomyces corchorusii) TR:Q54501(EMBL:X78535) chitin binding protein precursor Chb1 (201 aa), fasta scores opt: 1185 z-score: 1303.0 E():0 83.7% identity in 202 aa overlap and Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 1161 z-score: 1276.8 E(): 0 79.1% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (201 aa)    
Predicted Functional Partners:
SCO5673
SC8B7.05c, chiB, secreted chitinase, len: 610 aa; almost identical to S. lividans TR:D1026067 (EMBL:D84193) chitinase ChiB (EC 3.2.1.14) (610 aa), 99.3% identity in 610 aa overlap, and highly similar to many e.g. CHIX_STROI Streptomyces olivaceoviridis exochitinase 1 precursor (EC 3.2.1.14) (597 aa), fasta scores; opt: 3484 z-score: 2485.6 E(): 0, 86.1% identity in 596 aa overlap. Contains PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence.
 
  
 0.879
SCO5003
SCK15.05c, chiA, chinitase A precursor, len: 571 aa; identical to previously sequenced TR:Q9Z9M9 (EMBL:AB017008) Streptomyces coelicolor chinitase A precursor ChiA, 571 aa and to TR:Q59924 (EMBL:D13775) Streptomyces lividans chitinase A precursor (EC 3.2.1.14) ChiA, 571 aa. Contains Pfam match to entry PF02018 CBD_6, Cellulose binding domain, PF00041 fn3, Fibronectin type III domain, PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and matches to Prosite entries PS00678 Trp-Asp (WD) repeats signature and PS01095 Chitinases family 18 active site. Contains also possible N-terminal r [...]
 
  
 0.856
SCO5376
2SC6G5.20c, chiC, chitinase C (EC 3.2.1.14) (putative secreted protein), len: 609aa; previously sequenced as TR:Q9Z9M8 (EMBL:AB017010). Strongly similar to others from Streptomyces spp. e.g. SW:P11220 (CHIT_STRPL) chitinase 63 precursor from Streptomyces plicatus (610 aa) fasta scores; opt: 3997, z-score: 3833.9, E(): 0, 95.1% identity in 611 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18, Pfam match to entry PF00041 fn3, Fibronectin type III domain, Pfam match to entry PF00553 CBD_2, Cellulose binding domain, Prosite match to PS00561 Cel [...]
 
  
 0.798
SCO7337
Hypothetical protein; SC4G10.16, pepA2, unknown, len: 171 aa. Previously sequenced region: Streptomyces coelicolor TR:O54205(EMBL:AJ001206) hypothetical protein, PepA2 (171 aa).
      
 0.771
SCO1429
SC6D7.10, chiD, chitinase (putative secreted protein), len: 417 aa. Previously sequenced and characterised TR:Q9Z9M7(EMBL:AB017011) fasta scores opt: 2877 z-score: 3125.2 E():0 100.0% identity in 417 aa overlap. Contains a Pfam match to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and a Prosite hit to PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence.
 
   
 0.743
SCO2503
SCC121.06, probable chitinase precursor, len: 358 aa; similar to C-terminal region of SW:CHID_BACCI (EMBL:D10594) Bacillus circulans chitinase D precursor (EC 3.2.1.14) ChiD, 497 aa; fasta scores: opt: 471 z-score: 502.4 E(): 1.4e-20; 33.0% identity in 370 aa overlap and to SW:CHIX_STROI (EMBL:X71080) Streptomyces olivaceoviridis (Streptomyces corchorusii exochitinase 1 precursor (EC 3.2.1.14) Chi01, 597 aa; fasta scores: opt: 249 z-score: 267.3 E(): 1.7e-07; 31.2% identity in 391 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18 and match to Prosite enry PS01095 Chitinas [...]
 
  
 0.688
SCO7263
Chitinase; SC5H1.29c, chiF, chitinase, len: 296 aa; previously sequenced as chiF (EMBL:AB017012) and similar to many e.g. TR:O50152 (EMBL:AB009289), chiC, Streptomyces griseus chitinase C (294 aa), fasta scores; opt: 1308 z-score: 1506.5 E(): 0, 65.8% identity in 295 aa overlap. Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00182 chitinase_1, Chitinases class I, score 247.20, E-value 2.2e-70.
  
   
 0.675
SCO5954
SC7H1.24, probable chitinase (putative secreted protein), len: 765 aa; similar to many eg. S. lividans CHIT_STRLI P36909 chitinase c precursor (ec 3.2.1.14) (619 aa), fasta scores; opt: 292 z-score: 779.5 E(): 0, 35.1% identity in 752 aa overlap. Contains PS01095 Chitinases family 18 active site signature, and possible N-terminal region signal peptide sequence.
 
   
 0.646
SCO1444
SCL6.01, probable chitinase precursor, len: 791 aa; similar to TR:CAB62382 (EMBL:AJ250585) Arthrobacter sp chitinase precursor (EC 3.2.1.14) ChitIA, 880 aa; fasta scores: opt: 2788 z-score: 2817.6 E(): 0; 56.3% identity in 764 aa overlap and to SW:CHID_VIBFU (EMBL:U41418) Vibrio furnissii chitodextrinase precursor (EC 3.2.1.14) EndoI, 1046 aa; fasta scores: opt: 2055 z-score: 2075.7 E(): 0; 53.8% identity in 746 aa overlap. Contains three Pfam matches to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and match to Prosite entry PS01095 Chitinases family 18 active site. Cont [...]
 
  
 0.639
SCO6012
SC7B7.09c, probable hydrolase (putative secreted protein), len: 507 aa; similar to many chitinases eg. TR:Q59145 (EMBL:D31818) chitinase II precursor (EC 3.2.1.14) Aeromonas sp. (542 aa), fasta scores; opt: 410 z-score: 512.7 E(): 2.1e-21, 32.1% identity in 498 aa overlap. Contains N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop).
 
  
 0.634
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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