STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO3037Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (443 aa)    
Predicted Functional Partners:
SCO3036
Conserved hypothetical protein SCE34.18; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
 
 0.999
SCO5557a
Hypothetical protein SC7A1.01c; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
 
   
 0.919
SCO3038
SCE34.19, hypothetical protein, len: 326 aa; similar to TR:P96819 (EMB:LZ92770) Mycobacterium tuberculosis hypothetical 33.0 kD protein MTCI5.16, 308 aa; fasta scores: opt: 902 z-score: 980.1 E(): 0; 51.2% identity in 287 aa overlap and C-terminal region presents low similarity to SW:3MGA_BACSU (EMBLD14465:) Bacillus subtilis DNA-3-methyladenine glycosylase (EC 3.2.2.21) AlkA, 303 aa; fasta scores: opt: 146 z-score: 166.1 E(): 0.086; 23.6% identity in 208 aa overlap.
       0.793
SCO3313
SCE68.11c, conserved hypothetical protein, len: 305 aa; unknown function, N-terminal half similar to hypothetical proteins from Mycobacterium tuberculosis, Mycobacterium paratuberculosis and Streptomyces lividans, e.g. SW:Y08L_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical protein (149 aa), fasta scores; opt: 297 z-score: 354.1 E(): 2.1e-12, 42.7% identity in 124 aa overlap.
 
   
 0.788
SCO5971
SCBAC16H6.06, conserved hypothetical protein, len: 307 aa: similar to many e.g. TR:AAK45058 (EMBL:AE006971) hypothetical protein from Mycobacterium tuberculosis (347 aa) fasta scores; opt: 482, Z-score: 543.4, 32.399% identity (37.011% ungapped) in 321 aa overlap. Contains Pfam match to entry PF00296 bac_luciferase, Bacterial luciferase.
 
  
 0.783
SCO6786
SC6A5.35, possible oxidoreductase, len: 341aa; similar to many hypothetical proteins eg. TR:O53565 (EMBL:AL022022) from Mycobacterium tuberculosis (347 aa) fasta scores; opt: 800, z-score: 921.0, E(): 0, (38.9% identity in 339 aa overlap). Also similar to TR:O68447 (EMBL:AF041061) F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis (336 aa) fasta scores; opt: 198, z-score: 232.5, E(): 1.2e-05, (24.8% identity in 343 aa overlap).
 
  
 0.764
SCO4429
Conserved hypothetical protein SCD6.07; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
 
   
 0.751
SCO0775
3SCF60.07, conserved hypothetical protein, len: 149 aa; identical to TR:O85698 (EMBL:AF072709) Streptomyces lividans hypothetical 16.7 kDa protein, 149 aa and similar to SW:YF58_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis hypothetical 16.4 kDa protein MTCY48.07c, 148 aa; fasta scores: opt: 695 z-score: 894.5 E(): 0; 69.1% identity in 149 aa overlap.
 
   
 0.737
SCO1669
SCI52.11c, possible ATP/GTP-binding protein, len: 351 aa; similar to TR:O53565 (EMBL:AL022022) Mycobacterium tuberculosis hypothetical 37.6 kDa protein MTV023.27c, 347 aa; fasta scores: opt: 859 Z-score: 986.1 bits: 190.9 E(): 2.4e-47; 41.449% identity in 345 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
 
  
 0.724
SCO1625
SCI41.08, probable ribosomal pseudouridine synthase, len: 324 aa. Similar to SW:RLUA_ECOLI (EMBL:D10483) Escherichia coli ribosomal large subunit pseudouridine synthase 218 aa; fasta scores: opt: 262 z-score: 302.0 E(): 1.9e-09; 31.7% identity in 221 aa overlap. Contains Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family also PS01129 Rlu family of pseudouridine synthase signature.
  
    0.715
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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