STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3123Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)    
Predicted Functional Partners:
SCO3122
Putative nucleotidyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.
 
  
 0.983
SCO5281
SCCB12.05c, probable 2-oxoglutarate dehydrogenase, len: 1272 aa; similar to TR:P96746 (EMBL:D84102) Corynebacterium glutamicum 2-oxoglutarate dehydrogenase (EC 1.2.4.2) OdhA, 1257 aa; fasta scores: opt: 4321 z-score: 3452.7 E(): 0; 54.8% identity in 1262 aa overlap and to SW:ODO1_ECOLI (EMBL:J01619) Escherichia coli 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) SucA, 933 aa; fasta scores: opt: 2568 z-score: 2056.0 E(): 0; 46.5% identity in 881 aa overlap. Contains Pfam matches to entries PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and PF0 [...]
   
 0.983
SCO4086
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.965
SCO6497
SC1E6.06, tktA2, probable transketolase, len: 615 aa; highly similar to eukaryotic transketolases e.g. TKT_HUMAN transketolase (EC 2.2.1.1) (623 aa), fasta scores; opt: 1909 z-score: 2169.3 E(): 0, 50.0% identity in 614 aa overlap; less similar to prokaryotic transketolases e.g. TKT_RHOSH transketolase (657 aa), fasta scores; opt: 477 z-score: 830.4 E(): 0, 31.3% identity in 635 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 397.70, E-value 1.1e-115. Also similar to S. coelicolor tkt (SC5A7.13c) E(): 4.2e-20, 2 [...]
   
 
 0.957
SCO1269
Putative pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
   
 0.953
SCO3816
SCGD3.17c, bkdB1, probable branched-chain alpha keto acid dehydrogenase E1 beta subunit, len: 326 aa; similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716), BkdB, Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa), fasta scores; opt: 1188 z-score: 1395.2 E(): 0, 53.8% identity in 325 aa overlap and SW:ODPB_BACST (EMBL:X53560), PdhB, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (48.0% identity in 323 aa overlap). Highly simi [...]
   
 0.953
SCO3830
SCGD3.31c, bkdB2, probable branched-chain alpha keto acid dehydrogenase E1 beta subunit, len: 334 aa; similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716), BkdB, Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa), fasta scores; opt: 2063 z-score: 2427.3 E(): 0, 91.0% identity in 334 aa overlap and SW:ODPB_BACST (EMBL:X53560), PdhB, Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (45.5% identity in 319 aa overlap). Highly simi [...]
   
 0.953
SCO1935
Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.938
SCO6663
SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family.
   
 
 0.938
SCO3124
Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.937
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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