STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO3172Putative monooxygenase; Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3.2.0]hept- 2-en-6-one into the oxidative lactone products 2-oxabicyclo[3.3.0]oct- 6-en-3-one and 3-oxabicyclo[3.3.0]oct-6-en-2-one. Is also able to catalyze the sulfoxidation of methyl phenyl sulfide (thioanisole). Belongs to the FAD-binding monooxygenase family. (519 aa)    
Predicted Functional Partners:
SCO3173
SCE87.24, possible merR-family transcriptional regulator, len: 215 aa. Similar to two other putative transcriptional regulators from Streptomyces coelicolor TR:CAB40683 (EMBL:AL049587) SC5F2A.16C (251 aa), fasta scores opt: 210 z-score: 257.9 E(): 5.4e-07 32.3% identity in 217 aa overlap and TR:O86531 (EMBL:AL031124) SC1C2.31C (214 aa), fasta scores opt: 176 z-score: 218.8 E(): 8.2e-05 30.4% identity in 191 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family with the putative helix-turn-helix motif situated between residues 8..29 (+3.90 SD).
 
     0.909
SCO3171
SCE87.22c, possible hydrolase, len: 314 aa: Similar to several e.g. Mycobacterium tuberculosis TR:O53321 (EMBL: AL021646) hypothetical 32.1 KD protein (299 aa), fasta scores opt: 261 z-score: 297.3 E(): 3.5e-09 31.7% identity in 281 aa overlap and Streptomyces lividans SW:PRXC_STRLI (EMBL: U02635) non-heme chloroperoxidase (EC 1.11.1.10) (275 aa), fasta scores opt: 241 z-score: 275.2 E(): 5.9e-08 30.0% identity in 287 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
 
   0.900
SCO3170
SCE87.21c, probable 3-oxoacyl-[acyl carrier protein] reductase, len: 297 aa. Similar to many including: Mycobacterium tuberculosis TR:O33263 (EMBL:Z97559) probable oxidoreductase (293 aa), fasta scores opt: 672 z-score: 754.5 E(): 0 41.6% identity in 281 aa overlap and Escherichia coli SW:FABG_ECOLI (EMBL:M84991) 3-oxoacyl-[acyl carrier protein] reductase (244 aa), fasta scores opt: 354 z-score: 402.7 E(): 4.6e-15 31.3% identity in 195 aa overlap. Contains a Pfam match to entry PF00106 adh_short, short chain dehydrogenase and a Prosite hit to PS00061 Short-chain dehydrogenases/reductas [...]
 
     0.893
SCO3415
SCE9.22, probable esterase, len: 266 aa; similar to many e.g. SW:BAH_STRHY (EMBL:M64783), bah, Streptomyces hygroscopicus acetyl-hydrolase in bialaphos biosynthetic gene cluster (299 aa), fasta scores; opt: 637 z-score: 678.5 E(): 1.8e-30, 45.3% identity in 236 aa overlap. Contains PS01173 Lipolytic enzymes 'G-D-X-G' family, putative histidine active site.
  
 0.857
SCO1083
SCG22.29c, probable flavin-dependent reductase, len: 169 aa; similar to TR:O68503 (EMBL:AF048979) Rhodococcus erythropolis NADH-dependent FMN oxydoreductase DszD, 192 aa; fasta scores: opt: 444 z-score: 517.7 E(): 2.3e-21; 44.6% identity in 168 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain.
      
 0.787
SCO6729
SC5F2A.12c, putative membrane protein, len: 396 aa; similar to many e.g. TR:O53176 (EMBL:AL021246) hypothetical protein from Mycobacterium tuberculosis (419 aa) fasta scores; opt: 528, z-score: 598.4, E(): 5.1e-26, (41.0% identity in 420 aa overlap). Contains possible hydrophobic membrane spanning region.
  
     0.652
SCO6789
SC6A5.38, possible fatty oxidation protein, len: 733aa; similar to many eg. SW:FADB_ECOLI FadB, a multifunctional protein from the Escherichia coli fadBA operon, encoding the fatty acid-oxidizing multienzyme complex (729 aa) fasta scores; opt: 1119, z-score: 1146.7, E(): 0, (32.3% identity in 691 aa overlap). Contains Pfam matches to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase and a Prosite match to PS00923 Aspartate and glutamate racemases signature 1.
  
 
 
 0.639
SCO3169
Hypothetical protein SCE87.20c; SCE87.20c, unknown, len: 75 aa. Note the predicted product of this CDS has an unusual amino acid composition with an excess of Arg, Asp and Gln residues.
       0.636
SCO6732
SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...]
  
 
 
 0.632
SCO7131
SC4B10.32, possible lipase, len: 316 aa; similar to TR:O52270 (EMBL:AF034088) Pseudomonas sp. lipase (EC 3.1.1.-) LipP, 308 aa; fasta scores: opt: 675 z-score: 762.7 E(): 0; 38.0% identity in 303 aa overlap.
  
 0.543
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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