STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3188Putative methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (280 aa)    
Predicted Functional Partners:
SCO3014
Putative translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
 
 
 0.963
SCO3463
SCE46.20, probable phosphorylase, len: 262 aa; similar to TR:O58891 (EMBL:AP000005) Pyrococcus horikoshii 265 aa long hypothetical 5'-methylthioadenosine phosphorylase PH1143 265 aa; fasta scores: opt: 461 z-score: 534.1 E(): 2.1e-22; 35.1% identity in 251 aa overlap and to SW:MTAP_HUMAN (EMBL:U22233) Homo sapiens 5'-methylthioadenosine phosphorylase (EC 2.4.2.28) MtaP, 283 aa; fasta scores: opt: 373 z-score: 433.4 E(): 8.6e-17; 32.4% identity in 216 aa overlap. Contains Pfam match to entry PF00896 Mtap_PNP, phosphorylases family 2.
  
  
0.944
SCO2455
Putative spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
     
 0.936
SCO3655
Putative spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
     
 0.936
SCO1984
SC3C9.19c, probable hydrolase, len: 465 aa; similar to SW:ATZA_PSESD (EMBL:U55933) Pseudomonas sp. atrazine chlorohydrolase (EC 3.8.1.8) AtzA, 474 aa; fasta scores: opt: 448 Z-score: 490.2 bits: 100.0 E(): 1.1e-19; 33.258% identity in 445 overlap. Contains Pfam match to entry PF01685 ATZ_TRZ, Chlorohydrolase.
  
 
 0.911
SCO1514
Adenine phosphoribosiltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 
 0.887
SCO5443
Putative alpha-amylase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE- catalyzed polymerization with M1P. Is specific for the alpha-anomer of M1P as substrate, since the beta-anomer of M1P gives no activity. Alpha-D-glucose 1-phosphate cannot serve as a donor substrate, but alpha-maltosyl fluoride is an efficient donor in vitro. Exhibits an alpha-retaining catalytic [...]
      
 0.850
SCO3187
SCE22.04, hypothetical protein, len: 110 aa; similar to TR:O05574 (EMBL:Z94752) Mycobacterium tuberculosis hypothetical 11.4 kD protein MTCI237.05c, 110 aa; fasta scores: opt: 379 z-score: 372.3 E(): 2.8e-13; 52.3% identity in 107 aa overlap. High content in serine amino acid residue in C-terminal domain.
       0.767
SCO3189
SCE22.06, possible membrane protein, len: 159 aa. Contains possible hydrophobic membrane spanning region and high content in alanine amino acid residues.
       0.733
SCO3186
SCE22.03, possible ABC transporter integral membrane protein, len: 421 aa; similar to TR:O50532 (EMBL:AL009204) Streptomyces coelicolor hypothetical 41.1 kD protein SC9B10.25c, 393 aa; fasta scores: opt: 721 z-score: 787.1 E(): 0; 34.7% identity in 363 aa overlap. Contains match to Prosite entry PS00211 ABC transporters family signature and possible hydrophobic membrane spanning regions.
       0.716
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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