STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3201SCE22.18c, probable tetR-family transcriptional regulator, len: 236 aa; similar to TR:CAB62751 (EMBL:AL133424) Streptomyces coelicolor putative tetR-family transcriptional regulator SCF56.06, 213 aa; fasta scores: opt: 311 z-score: 346.2 E(): 8e-12; 38.1% identity in 194 aa overlap and to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR, 226 aa; fasta scores: opt: 254 z-score: 284.8 E(): 2.1e-08; 32.2% identity in 214 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-t [...] (236 aa)    
Predicted Functional Partners:
SCO1716
SCI11.05, possible gntR-family transcriptional regulator, len: 249 aa; weakly similar to many trancriptional regulators e.g. SW:FARR_ECOLI (EMBL:X15790), FarR, Escherichia coli fatty acyl responsive regulator (240 aa), fasta scores; opt: 213 z-score: 265.9 E(): 1.8e-07, 25.0% identity in 232 aa overlap. Similar to others from S.coelicolor e.g. SCE39.14c (EMBL:AL049573) S.coelicolor possible gntR-family regulator (243 aa) (29.5% identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 42-63 (Score 1296, +3.60 SD). Contains Pfam match to entry PF00392 gntR, Bacterial r [...]
   
  
 0.682
SCO0508
SCF6.04, possible tetR family transcriptional regulator, len: 180 aa. Similar to many e.g. Streptomyces glaucescens SW:TCMR_STRGA (EMBL:M80674) tetracenomycin C transcriptional repressor (226 aa), fasta scores opt: 225 z-score: 288.9 E(): 1e-08 34.5% identity in 174 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family with the possible helix-turn-helix motif between residues 13..34 (+3.92 SD).
  
     0.677
SCO5046
Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
      
 0.666
SCO0988
2SCG2.01, possible acetyltransferase, len: 230 aa. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
      
 0.647
SCO1809
Conserved hypothetical protein; SCI28.03c, unknown, len: 172aa; similar to SW:Y086_MYCTU hypothetical protein from Mycobacterium tuberculosis (158 aa) fasta scores; opt: 385, z-score: 471.9, E(): 5.9e-19, (43.5% identity in 161 aa overlap).
      
 0.647
SCO3021
SCE34.02, possible integral membrane protein, len: 318 aa; similar to TR:O69663 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 33.2 kD protein MTV025.043, 310 aa; fasta scores: opt: 734 z-score: 602.4 E(): 4.3e-26; 42.9% identity in 319 aa overlap. Contains possible hydrophobic membrane spanning regions.
      
 0.647
SCO4009
2SC10A7.13c, possible bifunctional protein (histidine kinase and regulator), len: 1463 aa; N-terminal region similar to TR:Q9RRR7 (EMBL:AE002072) Deinococcus radiodurans sensory box sensor histidine kinase DR2419, 744 aa; blastp scores: Score= 273 (96.1 bits), Expect= 3.4e-19, Sum P(2)= 3.4e-19; Identities= 112/386 (29%), Positives= 170/386 (44%) and C-terminal region similar to TR:Q9RKR9 (EMBL:AL133220) Streptomyces coelicolor putative multi-domain regulatory protein SCC75A.05c, 1334 aa; blastp scores: Score= 229 (80.6 bits), Expect= 6.8e-14, Sum P(3)= 6.8e-14; Identitie = 100/311 (32 [...]
      
 0.647
SCO4194
2SCD46.08, possible TetR-family transcriptional regulator, len: 213 aa; similar to many others from streptomycetes e.g. TR:CAB88457 (EMBL:AL353815) putative TetR-family transcriptional regulator from Streptomyces coelicolor (215 aa) fasta scores; opt: 369, z-score: 450.8, E(): 1.3e-17, 37.3% identity in 212 aa overlap and SW:P39885 (TCMR_STRGA) tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa) fasta scores; opt: 246, z-score: 303.8, E(): 2e-09, 36.7% identity in 166 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tet [...]
  
     0.603
SCO4450
SCD6.28, probable tetR-family transcriptional regulator, len: 215 aa; similar to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR, 226 aa; fasta scores: opt: 295 z-score: 356.1 E(): 2.2e-12; 33.5% identity in 218 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 39..60 (+4.31 SD).
  
     0.597
SCO6071
SC9B1.18, cprB, A-factor receptor homolog, len: 215 aa; previously sequenced therefore identical to TR:O66122 (EMBL:AB000385) CprB, A-factor receptor homolog from Streptomyces coelicolor. Also similar to many others from Actinomycetes e.g. TR:Q54189 (EMBL:D49782) A-factor receptor from Streptomyces griseus (276 aa) fasta scores; opt: 315, z-score: 392.1, E(): 1.6e-14, (36.5% identity in 219 aa overlap). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
  
   
 0.588
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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