STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3205SCE22.22, probable MarR-family transcriptional repressor, len: 163 aa; similar to TR:Q9X5U1 (EMBL:AF127374) Streptomyces lavendula repressor MmcW, 163 aa; fasta scores: opt: 724 z-score: 892.8 E(): 0; 65.4% identity in 162 aa overlap and to TR:CAB70635 (EMBL:AL137242) Streptomyces coelicolor putative transcriptional regulator SC8F4.09c, 158 aa; fasta scores: opt: 409 z-score: 459.2 E(): 4.8e-20; 43.2% identity in 146 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family. (163 aa)    
Predicted Functional Partners:
SCO3204
Hypothetical protein SCE22.21c; SCE22.21c, unknown, len: 253 aa; identical to previously sequenced TR:Q54224 (EMBL:X79980) Streptomyces griseus unknown gene, 253 aa and similar to SW:YGID_ECOLI (EMBL:M77129) Escherichia coli hypothetical 29.9 kD protein in TolC-RibB intergenic region (ORFC) YgiD, 271 aa; fasta scores: opt: 566 z-score: 655.8 E(): 4.6e-29; 38.5% identity in 262 aa overlap.
     
 0.927
SCO5533
SC1C2.14c, unknown, len: 185 aa; similar to hypothetical proteins from E. coli YCEI_ECOLI (191 aa), fasta scores; opt: 373 z-score: 567.7 E(): 2.3e-24, 34.1% identity in 179 aa overlap and H. pylori TR:O25873 (EMBL:AE000633) HP1286 (182 aa), fasta scores; opt: 279 z-score: 242.2 E(): 3.1e-06, 27.9% identity in 172 aa overlap; Belongs to the UPF0312 family.
 
   
 0.747
SCO5413
SC8F4.17, possible transcriptional regulator, len: 169 aa; similar to many proposed transcriptional regulators e.g. TR:CAB62730 (EMBL:AL133423) putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa) fasta scores; opt: 184, z-score: 242.7, E(): 4.1e-06, 35.1% identity in 111 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
 
   
 0.723
SCO5049
SCK7.22, hypothetical protein, len: 196 aa; similar to TR:P75894 (EMBL:AE000202) Escherichia coli hypothetical protein, 196 aa; fasta scores: opt: 466 z-score: 572.4 E(): 2e-24; 40.6% identity in 192 aa overlap and to SW:YDFN_BACSU (EMBL:AB001488) Bacillus subtilis putative NAD(P)H nitroreductase YdfN, 206 aa; fasta scores: opt: 133 z-score: 170.9 E(): 0.047; 23.1% identity in 199 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family. Similar also to TR:Q9FBV0 (EMBL:AL391072) Streptomyces coelicolor putative nitroreductase SC9A4.03c, 202 aa; fasta score [...]
   
  
 0.698
SCO2398
SC4A7.26, possible marR-family transcriptonal regulator, len: 151 aa; similar to TR:Q9WZS3 (EMBL:AE001749) Thermotoga maritima transcriptional regulator, putative, marR family TM0816, 142 aa; fasta scores: opt: 167 z-score: 210.9 E(): 0.00023; 31.7% identity in 139 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
      
 0.644
SCO2289
Putative membrane protein; SCC75A.35, possible membrane protein, len: 180 aa. Similar to several proteins of undefined function including: Bacillus subtilis TR:P96694(EMBL:AB001488) YdfP protein (129 aa), fasta scores opt: 308 z-score: 319.7 E(): 2e-10 42.4% identity in 125 aa overlap and Mycobacterium tuberculosis TR:O53252(EMBL:AL021287) (279 aa), fasta scores opt: 328 z-score: 335.2 E(): 2.7e-11 43.5% identity in 147 aa overlap. Contains possible membrane spanning hydrophobic domains.
       0.560
SCO3124
Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
   
  
 0.529
SCO7815
SC8E7.12 possible TetR-family transcriptional regulator, len: 223 aa. Highly similar to many putative regulators e.g. Mycobacterium tuberculosis TR:O53737 (EMBL:AL021932) putative transcriptional regulator (236 aa), fasta scores opt: 471 z-score: 574.1 E(): 1.7e-24 39.0% identity in 218 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family with a putative helix-turn-helix motif situated between residues 44..65 (+4.94 SD).
   
  
 0.515
SCO2916
Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
    0.506
SCO4967
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
     0.504
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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