STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3261SCE39.11, possible ATP-binding protein, len: 431 aa; limited similarity to others of unknown function eg. TR:Q47527 (EMBL:Z12832) hypothetical ATP-binding protein from Escherichia coli (492 aa) fasta scores; opt: 239, z-score: 271.8, E(): 7.9e-08, (32.0% identity in 153 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (431 aa)    
Predicted Functional Partners:
SCO3262
Hypothetical protein; SCE39.12, unknown, len: 249aa; limited similarity to others of unknown function some of which are associated with bacteriophage eg. SW:VE31_LAMBD protein EA31 from bacteriophage lambda (296 aa) fasta scores; opt: 133, z-score: 164.9, E(): 0.071, (35.3% identity in 85 aa overlap). Contains TTA codon, possible target for bldA regulation.
 
   
 0.996
SCO2863
SCE20.37, possible helicase, len: 945 aa. Weakly similar to Saccharomyces cerevisiae (Baker's yeast) TR:Q06683(EMBL:U32517) DEAD box family helicase family protein (689 aa), fasta scores opt: 455 z-score: 511.5 E(): 4.1e-21 27.2% identity in 357 aa overlap. Also weakly similar to several bacteriophage proteins including: Lactococcus bacteriophage (isolate 7-9) SW:V51K_BPL79 (EMBL:M36388) 51.5 KD protein which may play a role in either regulating bacteriophage replication or bacteriophage specific genes (452 aa), fasta scores opt: 407 z-score: 460.0 E(): 3.1e-18 27.4% identity in 328 aa [...]
     
 0.887
SCO4213
Hypothetical protein; 2SCD46.27, unknown, len: 544 aa; C-terminal region similar to that of SW:P24202 (MRR_ECOLI) Mrr restriction system protein from Escherichia coli (304 aa) fasta scores; opt: 199, z-score: 216.8, E(): 0.00013, 28.4% identity in 162 aa overlap. N-terminal region contains possible coiled-coil sequences residues (33-63 and 156-200) and two TTA encoded leucine residues which may be a target for bldA regulation.
     
 0.863
SCO3510
SCE134.11c, possible DNA methylase, len: 248 aa; similar to many e.g. TR:O68789 (EMBL:AF053947) adenine methyltransferase homolog from Yersinia pestis (213 aa) fasta scores; opt: 246, z-score: 300.2, E(): 2.1e-09, (30.8% identity in 224 aa overlap). Contains Prosite match to PS00092 N-6 Adenine-specific DNA methylases signature; Belongs to the N(4)/N(6)-methyltransferase family.
 
   
 0.717
SCO5330
SC6G9.03c, hypothetical protein, len: 300 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition.
      
 0.670
SCO3104
Hypothetical protein SCE41.13c; SCE41.13c, unknown, len: 679 aa.
     
 0.667
SCO3105
Hypothetical protein SCE41.14; SCE41.14, unknown, len: 201 aa.
      
 0.647
SCO3509
Conserved hypothetical protein; SCE134.10, unknown, len: 320 aa; weakly similar to SW:YD75_HAEIN hypothetical protein from Haemophilus influenzae (302 aa) fasta scores; opt: 308, z-score: 377.0, E(): 1.1e-13, (23.6% identity in 301 aa overlap) and similar to TR:Q9L1X0 (EMBL:AL138667) Streptomyces coelicolor hypothetical protein SC3D9.09, 350 aa; fasta scores: opt: 589 Z-score: 696.5 E(): 3.6e-31; 46.006% identity in 313 aa overlap.
      
 0.647
SCO7701
Putative methyltransferase; Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).
  
     0.638
SCO6885
SC7F9.37, possible DNA methylase, len: 251 aa. Similar to many methylases e.g. Moraxella bovis SW:MT1C_MORBO(EMBL:D13968) modification methylase MboI (EC 2.1.1.72) (273 aa), fasta scores opt:208 z-score: 250.5 E(): 1.5e-06 24.5% identity in 253 aa overlap and Streptomyces coelicolor TR:Q9X866(EMBL:AL049661) putative DNA methylase, SCE134.11c (248 aa), fasta scores opt: 976 z-score: 1145.8 E():0 57.6% identity in 250 aa overlap. Contains a Prosite hit to PS00092 N-6 Adenine-specific DNA methylases signature and a Pfam match to entry PF01555 N6_N4_Mtase, DNA methylase; Belongs to the N(4 [...]
 
   
 0.580
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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