STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3314SCE68.12c, possible dehydrogenase, len: 318 aa; weakly similar to SW:QOR_CAVPO (EMBL:M26936) Cavia porcellus quinone oxidoreductase (329 aa), fasta scores; opt: 301 z-score: 320.4 E(): 1.6e-10, 27.6% identity in 326 aa overlap. Similar to TR:Q53927 (EMBL:X62373) ORF2 from S.coelicolor actVI locus (329 aa) (33.7% identity in 329 aa overlap). Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. (318 aa)    
Predicted Functional Partners:
SCO3315
SCE68.13, probable transcriptional regulator, len: 230 aa; similar to TR:O53612 (EMBL:AL021428) Mycobacterium tuberculosis putative transcriptional regulator (189 aa), fasta scores; opt: 315 z-score: 346.2 E(): 5.8e-12, 35.5% identity in 172 aa overlap. Weak similarity to TR:O54180 (EMBL:AL021411), SC7H1.22, S.coelicolor probable transcriptional regulator (203 aa) (34.4% identity in 154 aa overlap). Contains probable helix-turn-helix motif at aa 50-71 (Score 1594, +4.62 SD). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family (weak match).
       0.577
SCO3313
SCE68.11c, conserved hypothetical protein, len: 305 aa; unknown function, N-terminal half similar to hypothetical proteins from Mycobacterium tuberculosis, Mycobacterium paratuberculosis and Streptomyces lividans, e.g. SW:Y08L_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical protein (149 aa), fasta scores; opt: 297 z-score: 354.1 E(): 2.1e-12, 42.7% identity in 124 aa overlap.
   
   0.425
SCO1698
Conserved hypothetical protein; SCI30A.19, unknown, len: 153 aa; similar to many of undefined function e.g. TR:P96807 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (151 aa) fasta scores; opt: 639, z-score: 785.9, E(): 0, (60.8% identity in 148 aa overlap) and SW:NODN_RHILV nodulation protein from Rhizobium leguminosarum (161 aa) fasta scores; opt: 388, z-score: 482.2, E(): 1.6e-19, (44.8% identity in 145 aa overlap).
 
 
 0.407
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.