STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3320Conserved hypothetical protein; Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance; Belongs to the transcriptional regulatory Rex family. (258 aa)    
Predicted Functional Partners:
SCO3317
SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...]
       0.875
SCO3318
Putative porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
       0.875
SCO3319
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
       0.875
SCO3881
Putative ribonuclease P component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
   
    0.816
SCO3321
SCE68.19c, possible redoxin, len: 101 aa; similar to TR:O69271 (EMBL:Y09572), NrdH, Corynebacterium ammoniagenes NrdH-redoxin from a ribonucleotide reductase operon (75 aa), fasta scores; opt: 96 z-score: 145.6 E(): 0.88, 27.6% identity in 76 aa overlap. Also similar to SW:YV35_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (97 aa) (33.3% identity in 75 aa overlap). Cys32 and Cys35 are conserved in similar proteins.
  
  
 0.761
SCO3322
SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain.
     
 0.683
SCO5591
SC2E1.08, rpsP, 30S ribosomal protein S16, highly similar to many e.g. RS16_MYCTU (162 aa), fatsa scores; opt:480 z-score: 771.3 E(): 0, 56.3% identity in 144 aa overlap. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family.
   
    0.612
SCO4209
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
  
 0.581
SCO3311
Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family.
       0.560
SCO3324
SCE68.22, hypothetical protein, len: 419 aa; unknown function, probable serine-rich CDS suggested by positional base preference, GC frame analysis and amino acid composition. An alternative start codon is present at codon 4.
       0.560
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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