STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3478SCE65.14c, probable dehydrogenase, len: 344 aa; similar to TR:O50095 (EMBL:AP000006) Pyrococcus horikoshii 307aa long hypothetical phosphoglycerate dehydrogenase PH1387, 307 aa; fasta scores: opt: 687 z-score: 777.1 E(): 0; 40.5% identity in 291 aa overlap and to SW:SERA_METTH (EMBL:AE000870;) Methanobacterium thermoautotrophicum D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 525 aa; fasta scores: opt: 664 z-score: 748.1 E(): 0; 39.0% identity in 282 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite [...] (344 aa)    
Predicted Functional Partners:
SCO4366
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.970
SCO5515
SC8D9.27, serA, D-3-phosphoglycerate dehydrogenase, len: 529 aa; member of a family including egs. SW:SERA_MYCLE putative SerA, D-3-phosphoglycerate dehydrogenase from Mycobacterium leprae (528 aa) fasta scores; opt: 1889, z-score: 2032.0, E(): 0, (56.9% identity in 524 aa overlap) and SW:SERA_BACSU SerA, D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (525 aa) fasta scores; opt: 1176, z-score: 1266.5, E(): 0, (39.7% identity in 529 aa overlap). Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, PS00670 D-isomer specific 2-hydroxyacid dehyd [...]
  
  
 
0.917
SCO4209
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
  
 0.914
SCO6818
Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.905
SCO3477
SCE65.13c, possible dehydrogenase, len: 344 aa; similar to TR:CAB50292 (EMBL:AJ248287) Pyrococcus abyssi threonine 3-dehydrogenase (EC 1.1.1.103) 348 aa; fasta scores: opt: 567 z-score: 616.8 E(): 5.6e-27; 33.8% identity in 328 aa overlap and to SW:TDH_BACSU (EMBL:Z99112) threonine 3-dehydrogenase (EC 1.1.103) Tdh, 347 aa; fasta scores: opt: 544 z-score: 592.1 E(): 1.3e-25; 31.4% identity in 331 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases.
 
   
 0.814
SCO3476
Putative short-chain dehydrogenase; SCE65.12c, probable dehydrogenase, len: 251 aa; similar to SW:KDUD_BACSU (EMBL:L47838) Bacillus subtilis 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) KduD, 254 aa; fasta scores: opt: 833 z-score: 937.8 E(): 0; 52.0% identity in 248 aa overlap and to Streptomyces coelicolor SCI30A.02, 253 aa; fasta scores: opt: 605 z-score: 622.2 E(): 2.7e-29; 44.1% identity in 245 aa overlap. Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to [...]
 
   0.806
SCO5355
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
  
 0.484
SCO0420
SCF51.19c, possible homoserine dehydrogenase, len: 344 aa; similar to SW:DHOM_SYNY3 (EMBL:D64001) Synechocystis sp. (strain PCC 6803) homoserine dehydrogenase (EC 1.1.1.3) (HDH), 433 aa; fasta scores: opt: 284 z-score: 307.6 E(): 9.2e-10; 29.0% identity in 335 aa overlap and to TR:O26517 (EMBL:AE000826) Methanobacterium thermoautotrophicum homoserine dehydrogenase homologue MTH417, 340 aa; fasta scores: opt: 332 z-score: 359.9 E(): 1.1e-12; 30.1% identity in 335 aa overlap. Contains Prosite match to entry PS01042 Homoserine dehydrogenase signature.
 
 
 0.464
SCO3475
SCE65.11c, possible isomerase, len: 377 aa; similar to SW:ATB_RHOOP (EMBL:X99622) Rhodococcus opacus muconate cycloisomerase I (EC 5.5.1.1) CatB, 373 aa; fasta scores: opt: 390 z-score: 443.3 E(): 2.6e-17; 31.1% identity in 357 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
       0.451
SCO1657
Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
  
 0.439
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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