STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3541SCH5.03c, possible DNA polymerase, len: 401 aa; limited region of similarity to many DNA polymerase III subunits e.g. SW:DP3X_SALTY DNA polymerase III subunits gamma and tau from Salmonella typhimurium (642 aa) fasta scores; opt: 327, z-score: 338.5, E(): 1.5e-11, (32.1% identity in 246 aa overlap). Contains probable coiled-coil region from 245 to 285 (41 residues), max score: 1.601, (probability 0.99). (401 aa)    
Predicted Functional Partners:
SCO2564
SCC123.02c, possible DNA-binding protein, len: 336 aa. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P71730 (EMBL:Z81368) hypothetical 33.1 KD protein (316 aa), fasta scores opt: 792 z-score: 880.3 E():0 42.4% identity in 316 aa overlap. Note that codon 21 may be an alternative translational start site. Contains a possible helix-turn-helix motif situated between residues 263..284 (+2.96 SD).
 
 
 0.996
SCO3878
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
 
 
 0.991
dnaN
Putative DNA-polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]
 
 
 0.990
SCO2064
DNA polymerase III alpha chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
 
 0.989
SCO6084
SCBAC1A6.08, possible DNA polymerase, len: 244 aa; similar to SW:DP3E_ECOLI (EMBL:X04027) Escherichia coli DNA polymerase III, epsilon chain (EC 2.7.7.7) DnaQ, 243 aa; fasta scores: opt: 137 z-score: 167.9 E(): 0.089; 26.2% identity in 206 aa overlap and to TR:Q9L275 (EMBL:AL137778) Streptomyces coelicolor putative DNA polymerase III SCL2.24, 241 aa; fasta scores: opt: 580 z-score: 680.3 E(): 2.6e-30; 42.7% identity in 234 aa overlap. Contains Pfam match to entry PF00929 Exonuclease, Exonuclease.
  
 0.987
dnaE
SCP1.224c, dnaE, probable DNA polymerase III, alpha chain (EC 2.7.7.7), len: 1213aa; similar to many eg. SW:Q10779 (DP3A_MYCTU) probable DNA polymerase III, alpha chain from Mycobacterium tuberculosis (1184 aa) fasta scores; opt: 3067, z-score: 3382.7, E(): 0, 55.8% identity in 1200 aa overlap and SW:P10443 (DP3A_ECOLI) DNA polymerase III, alpha chain (EC 2.7.7.7) from Escherichia coli (1160 aa) fasta scores; opt: 845, z-score: 927.5, E(): 0, 36.2% identity in 1178 aa overlap. Contains Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region.
 
 0.987
SCO1534
SCL2.24, possible DNA polymerase III, len: 241 aa; similar to SW:DP3E_RICPR (EMBL:AJ235273) Rickettsia prowazekii DNA polymerase III, epsilon chain (EC 2.7.7.7) DnaQ, 229 aa; fasta scores: opt: 200 z-score: 245.9 E(): 2.7e-06; 26.7% identity in 195 aa overlap and to SW:DP3E_ECOLI (EMBL:X04027) Escherichia coli DNA polymerase III, epsilon chain (EC 2.7.7.7) DnaQ, 243 aa; fasta scores: opt: 148 z-score: 184.0 E(): 0.0078; 27.6% identity in 181 aa overlap. Contains Pfam match to entry PF00929 Exonuclease.
  
 0.975
SCO1827
SCI8.12, possible DNA polymerase III, epsilon chain (EC 2.7.7.7), len: 328 aa. Similar to many including: Mycobacterium tuberculosis TR:O69678 (EMBL: AL022121) hypothetical 35.8 KD protein (329 aa), fasta scores opt: 509 z-score: 584.3 E(): 3.6e-25 41.6% identity in 315 aa overlap and Escherichia coli SW: DP3E_ECOLI (EMBL: X04027) DNA polymerase III, epsilon chain (EC 2.7.7.7) (243 aa), fasta scores opt: 251 z-score: 293.6 E(): 5.5e-09 27.9% identity in 204 aa overlap. Contains a Pfam match to entry PF00929 Exonuclease, Exonuclease.
   
 0.971
SCO2683
SCC61A.04c, possible single-strand DNA-binding protein, len: 156 aa; similar to many eg. SW:P71711 (SSB_MYCTU) single-strand binding protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 259, z-score: 301.8, E(): 2.4e-09, 35.5% identity in 141 aa overlap and TR:Q9X8U3 (EMBL:AL049826) putative single-strand binding protein from Streptomyces coelicolor (199 aa) fasta scores; opt: 261, z-score: 302.7, E(): 2.1e-09, 42.5% identity in 120 aa overlap. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family.
 
 
 
 0.931
SCO4067
DNA polymerase III subunit gamma; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
  
 
0.927
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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