STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
SCO3543Probable DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] (952 aa)    
Predicted Functional Partners:
SCO5188
2SC3B6.12, probable ATP-dependent DNA helicase, len: 785 aa; similar to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD, 720 aa; fasta scores: opt: 649 z-score: 632.5 E(): 9.2e-28; 31.6% identity in 643 aa overlap. Contains 2x Pfam matches to entry PF00580 UvrD-helicase, UvrD/REP helicase, Pfam match to entry PF00570 HRDC, HRDC domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
 
 0.995
SCO5815
SC5B8.05, probable ATP-dependent DNA helicase, len:7 19 aa; similar in N-terminal half to many e.g. RECQ_ECOLIP1 5043 atp-dependent dna helicase recq (607 aa), fasta score s; opt: 546 z-score: 615.9 E(): 4.1e-27, 35.9% identity in 362 aa overlap. Contains PS00690 DEAH-box subfamily ATP-dep endent helicases signature and Pfam match to entry helicase _C PF00271, Helicases conserved C-terminal domain, score 91 .14.
  
 0.982
SCO5769
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.980
SCO4577
SCD16A.06c, probable helicase, len: 676aa; similar to many (both prokaryote and eukaryote) egs. TR:AAD05424 (EMBL:AF047374) RecQ helicase from Neisseria gonorrhoeae (767 aa) fasta scores; opt: 1809, z-score: 1769.1, E(): 0, (50.4% identity in 601 aa overlap) and SW:HUS2_SCHPO ATP-dependent helicase from Schizosaccharomyces pombe (1328 aa) fasta scores; opt: 1013, z-score: 988.7, E(): 0, (40.2% identity in 493 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, score 78.40, E-value 1.4e-19.
 
 0.972
SCO2003
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.956
SCO2571
SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V).
 
 
 
 0.904
SCO6160
Putative SecDF protein-export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
  
 0.886
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.871
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
 
  
 0.869
SCO3873
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
   
 0.859
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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