STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3596Putative D-alanine:D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor. (202 aa)    
Predicted Functional Partners:
SCO3595
Putative D-alanine:D-lactate ligase; Required for resistance to glycopeptides antibiotics. D-Ala-- D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate by D-alanine but by D-lactate, thus preventing vancomycin binding (By similarity); Belongs to the D-alanine--D-alanine ligase family.
 
   
 0.994
SCO2328
Putative dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
  
  
 0.969
SCO3594
SC66T3.05, dldh, probable D-lactate dehydrogenase, len: 337 aa; highly similar to many e.g. TR:O33805 (EMBL:U8296) Streptomyces toyocaensis D-lactate dehydrogenase (330 aa), fasta scores; opt: 1470 z-score: 1711.8 E(): 0,71.4% identity in 318 aa overlap. Also similar to D-specific alpha-keto acid dehydrogenases from vancomycin-resistant bacteria e.g. SW:VANH_ENTFC (EMBL:M64304), VanH, Enterococcus faecium alpha-keto acid dehydrogenase (322 aa) (61.4% identity in 316 aa overlap). Similar to other S.coelicolor putative dehydrogenases e.g. part of SerA (EMBL:AL035569) S.coelicolor probabl [...]
 
   
 0.953
SCO1396
Putative D-alanyl-D-alanine dipeptidase (putative secreted protein); Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
  
  
 
0.911
SCO3593
SC66T3.04, hypothetical protein, len: 397 aa; unknown function, weakly similar to many femA proteins e.g. SW:FEMA_STAAU (EMBL:M23918), FemA, Staphylococcus aureus factor essential for expression of methicillin resistance (433 aa), fasta scores; opt: 184 z-score: 218.4 E(): 7.7e-05, 23.3% identity in 434 aa overlap. Similar to SCH24.26c (EMBL:AL049826) S.coelicolor hypothetical protein (373 aa) (50.4% identity in 387 aa overlap).
     
 0.828
SCO3589
SCH66.10c, probable two component sensor kinase, len: 364 aa; similar to many e.g. SW:CUTS_STRCO two component sensor kinase involved in the regulation of copper uptake in Streptomyces coelicolor (414 aa) fasta scores; opt: 659, z-score: 768.1, E(): 0, (35.6% identity in 390 aa overlap). Contains Pfam matches to entry PF00512 signal, Signal carboxyl-terminal domain and to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains possible hydrophobic membrane spanning regions.
 
   
 0.780
SCO3590
SC66T3.01c, probable two-component system response regulator, partial CDS, len: >62 aa; similar to many e.g. SW:CUTR_STRCO (EMBL:X58793), CutR, S.coelicolor two component response regulator involved in regulation of copper metabolism (217 aa), fasta scores; opt: 231 z-score: 316.5 E(): 2.7e-10, 56.5% identity in 62 aa overlap. The CDS continues as SCH66.11c in cosmid H66 (EMBL:AL049731); SCH66.11c, probable two component response regulator, len: 213 aa; similar to many e.g. SW:CUTR_STRCO two component response regulator involved in regulation of copper uptake in Streptomyces coelicolor [...]
 
   
 0.747
SCO5560
D-alanine-D-alanine ligase; Cell wall formation.
     
 0.713
SCO2088
Putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
     
 0.685
SCO3592
SC66T3.03, possible membrane protein, len: 330 aa; similar to TR:Q9L038 (EMBL:AL352956) Streptomyces coelicolor putative membrane protein SC1H10.06c, 301 aa; fasta scores: opt: 557 Z-score: 630.1 E(): 1.8e-27; 50.968% identity in 310 aa overlap. Contains hydrophobic, possible membrane-spanning regions at the N-terminus region.
     
 0.637
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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