STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3615SC66T3.26c, ask, probable aspartokinase, len: 425 aa; highly similar to many e.g. SW:AKAB_MYCSM (EMBL:Z17372), ask, Mycobacterium smegmatis aspartokinase (421 aa), fasta scores; opt: 1839 z-score: 1990.8 E(): 0, 67.4% identity in 427 aa overlap. Homologous genes encode both the alpha and beta subunits of ask by using alternative initiation codons. Codon 253 represents the equivalent position in this sequence, by similarity. Contains Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases and PS00324 Aspartokinase signature. (425 aa)    
Predicted Functional Partners:
SCO3614
Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 
 0.999
SCO2640
Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 
 0.996
SCO5354
SCBAC5H2.23, thrA, homoserine dehydrogenase, len: 429 aa; highly similar to SW:DHOM_CORGL (EMBL:Y00546) Corynebacterium glutamicum homoserine dehydrogenase (EC 1.1.1.3) Hom or ThrA, 445 aa; fasta scores: opt: 1592 z-score: 1742.3 E(): 0; 57.7% identity in 423 aa overlap. Contains Pfam matches to entries PF00742 Homoserine_dh, Homoserine dehydrogenase and PF01842 ACT, ACT domain and match to Prosite entry PS01042 Homoserine dehydrogenase signature. Note: Can participate in the biosynthesis of Methionine, Lysine and Threonine (plus following steps to Valine, Leucine and Isoleucine).
 
 0.912
SCO0386
SCF62.12, putative asparagine synthetase, len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL; Z70283) putative asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa), fasta scores opt: 752 z-score: 874.8 E():0 32.8% identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II.
  
 
 0.884
SCO5356
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.880
SCO7036
SC4G1.02, argG, argininosuccinate synthase, len: 481 aa; identical to previously sequenced SW:ASSY_STRCO (EMBL:D00799) Streptomyces coelicolor argininosuccinate synthase (EC 6.3.4.5) ArgG, 480 aa. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase and matches to Prosite entries PS00564 Argininosuccinate synthase signature 1 and PS00565 Argininosuccinate synthase signature 2; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
  
 
 0.880
SCO5744
Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.861
SCO4645
SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
  
 0.853
SCO5355
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.846
SCO3629
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.843
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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