STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3621SC66T3.32c, probable serine-threonine protein kinase, len: 783 aa; N-terminal half similar to the corresponding region of several serine-threonine protein kinases e.g. SW:AFSK_STRCO (EMBL:D15062), afsK, S.coelicolor serine-threonine protein kinase (799 aa), fasta scores; opt: 944 z-score: 519.3 E(): 1.3e-21, 45.6% identity in 379 aa overlap. The central region contains 26x slightly degenerate GG(A/V)G(P/S) repeats. Contains two Pfam matches to entry PF00069 pkinase, Eukaryotic protein kinase domain, PS00108 Serine/Threonine protein kinases active-site signature and PS00107 Protein kina [...] (783 aa)    
Predicted Functional Partners:
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.857
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 
 0.852
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.831
SCO2450
SCC24.21, possible serine/threonine protein kinase (regulator), len: 1349 aa; N-terminal region similar to SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa; blastp socres: Score = 109 (38.4 bits), Expect = 0.00070, Sum P(2) = 0.00070 Identities = 39/121 (32%), Positives = 60/121 (49%) and C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR, 993 aa; fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17; 33.3% identity in 442 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryoti [...]
  
 
   0.783
SCO4776
SCD63.08, possible serine/threonine protein kinase, len: 979 aa; similar to TR:O83032 (EMBL:AB16932) Streptomyces coelicolor protein serine/threonine kinase PhaD, 598 aa; blastp scores: Sum P(2) = 2.4e-24 Identities = 123/403 (30%), Positives = 159/403 (39%). Contains 2x Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and possible hydrophobic membrane spanning region. High content in alanine, glycine and proline residues.
  
   
 0.731
SCO5544
Putative membrane protein SC1C2.25c; SC1C2.25c, cvnA1, unknown, len: 1329 aa; contains two possible transmembrane domains at around 100 and 400 aa, and probable coiled-coil domains from 112 to 144 and 360 to 398. Overall 35.6% identical to downstream gene SC1C2.22c, but with much higher similarity between aa 468 and 709.
    
 
 0.671
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.661
SCO2110
SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...]
 
 
0.654
SCO3848
SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...]
 
 
0.652
SCO3360
Hypothetical protein; SCE94.11c, unknown, len: 277aa; previously sequenced therefore identical to TR:E1358529 (EMBL:AJ131213) hypothetical protein from Streptomyces coelicolor (277 aa) fasta scores; opt: 1897, z-score: 2249.5, E(): 0, (99.6% identity in 277 aa overlap).
      
 0.648
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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