STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3649Putative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)    
Predicted Functional Partners:
SCO1945
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
  
 
 0.990
SCO0578
SCF55.02c, possible triosephosphate isomerase, len: 259 aa; similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA, 261 aa; fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20; 38.9% identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM, Triosephosphate isomerase.
  
 
 0.988
SCO1947
Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]
  
 0.988
SCO7511
SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...]
  
 0.986
SCO7040
SC4G1.06c, gap2, glyceraldehyde-3-phosphate dehydrogenase, len: 481 aa; highly similar to TR:O68923 (EMBL:AF058302) Streptomyces roseofulvus glyceraldehyde-3-phosphate dehydrogenase homolog GapX, 461 aa; fasta scores: opt: 2562 z-score: 2921.8 E(): 0; 84.5% identity in 459 aa overlap and to many eukaryotic homologos, e.g. SW:G3PA_MAIZE (EMBL:X15408) Zea mays glyceraldehyde-3-phosphate dehydrogenase A, chloroplast precursor (EC 1.2.1.12) GapA, 403 aa; fasta scores: opt: 793 z-score: 907.5 E(): 0; 39.6% identity in 366 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde [...]
  
 0.983
SCO3196
SCE22.13c, probable fructose-specific permease, len: 699 aa; similar to SW:PTFB_ECOLI (EMBL:M23196) Escherichia coli PTS system, fructose-specific IIBC component (EIIBC-fru) FruA 563 aa; fasta scores: opt: 1006 z-score: 1038.9 E(): 0; 43.7% identity in 583 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible hydrophobic membrane spanning regions in C-terminal domain.
  
 
 0.982
SCO7638
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.978
SCO1942
SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...]
  
 
 0.974
SCO6659
SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266.
  
 
 0.974
SCO3096
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.971
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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